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Rabbit Anti-ELF4 Recombinant Antibody (EG1085) (CBMAB-EN1281-LY)

The product is antibody recognizes ELF4. The antibody EG1085 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:10000.
See all ELF4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG1085
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human ELF4.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
E74 Like ETS Transcription Factor 4
Introduction
The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
Entrez Gene ID
Human2000
Mouse56501
UniProt ID
HumanQ99607
MouseQ9Z2U4
Alternative Names
E74 Like ETS Transcription Factor 4; E74-Like Factor 4 (Ets Domain Transcription Factor); Myeloid Elf-1-Like Factor; ELFR; MEF; ETS-Related Transcription Factor Elf-4; E74-Like Factor 4;
Research Area
Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity).

Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity).

Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.
Biological Process
Cell differentiation Source: GO_Central
Innate immune response Source: InterPro
Natural killer cell proliferation Source: UniProtKB
NK T cell proliferation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
PML body. Accumulation into PML nuclear bodies is mediated by PML.
Involvement in disease
A chromosomal aberration involving ELF4 has been found in a case of acute myeloid leukemia (AML). Translocation t(X;21)(q25-26;q22) with ERG.

Liu, T., Yu, H., Zhang, Z., Xie, Y., Yang, L., & You, F. (2022). Intestinal ELF4 Deletion Exacerbates Alcoholic Liver Disease by Disrupting Gut Homeostasis. International journal of molecular sciences, 23(9), 4825.

Sun, G., Qiu, L., Yu, L., An, Y., Ding, Y., Zhou, L., ... & Du, H. (2022). Loss of function mutation in ELF4 causes autoinflammatory and immunodeficiency disease in human. Journal of Clinical Immunology, 1-13.

Kosti, A., Chiou, J., Guardia, G. D., Lei, X., Balinda, H., Landry, T., ... & Penalva, L. O. (2022). ELF4 is a critical component of a miRNA-transcription factor network and is a bridge regulator of glioblastoma receptor signaling and lipid dynamics. Neuro-oncology.

Sze, K. M. F., Ho, D. W. H., Chiu, Y. T., Tsui, Y. M., Chan, L. K., Lee, J. M. F., ... & Ng, I. O. L. (2021). Hepatitis B Virus–Telomerase Reverse Transcriptase Promoter Integration Harnesses Host ELF4, Resulting in Telomerase Reverse Transcriptase Gene Transcription in Hepatocellular Carcinoma. Hepatology, 73(1), 23-40.

Gong, R., Li, Z. Q., Fu, K., Ma, C., Wang, W., & Chen, J. C. (2021). Long noncoding RNA PVT1 promotes stemness and temozolomide resistance through miR-365/ELF4/SOX2 axis in glioma. Experimental Neurobiology, 30(3), 244.

Zhao, H., Xu, D., Tian, T., Kong, F., Lin, K., Gan, S., ... & Li, G. (2021). Molecular and functional dissection of EARLY-FLOWERING 3 (ELF3) and ELF4 in Arabidopsis. Plant Science, 303, 110786.

Tyler, P. M., Bucklin, M. L., Zhao, M., Maher, T. J., Rice, A. J., Ji, W., ... & Lucas, C. L. (2021). Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation. Nature immunology, 22(9), 1118-1126.

Kafita, D., Daka, V., Nkhoma, P., Zulu, M., Zulu, E., Tembo, R., ... & Munsaka, S. (2021). High ELF4 expression in human cancers is associated with worse disease outcomes and increased resistance to anticancer drugs. Plos one, 16(4), e0248984.

Chen, W. W., Takahashi, N., Hirata, Y., Ronald, J., Porco, S., Davis, S. J., ... & Mas, P. (2020). A mobile ELF4 delivers circadian temperature information from shoots to roots. Nature plants, 6(4), 416-426.

Kosti, A., Du, L., Shivram, H., Qiao, M., Burns, S., Garcia, J. G., ... & Penalva, L. O. (2020). ELF4 Is a Target of miR-124 and Promotes Neuroblastoma Proliferation and Undifferentiated StatemiR-124 Differentiates Neuroblastoma through ELF4. Molecular Cancer Research, 18(1), 68-78.

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For research use only. Not intended for any clinical use.

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