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  • Mouse Anti-ELF4 Recombinant Antibody (CBFYE-0776)

Mouse Anti-ELF4 Recombinant Antibody (CBFYE-0776) (V2LY-0825-LY71)

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Datasheet
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBFYE-0776
Application
WB, IP, IF, ELISA
Immunogen
Amino acids 521-663 within C-terminus of human Elf-4.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, gelatin
Preservative
Sodium azide
Concentration
0.2 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
E74 Like ETS Transcription Factor 4
Entrez Gene ID
Human2000
Mouse56501
Rat302811
UniProt ID
HumanQ99607
MouseQ9Z2U4
RatD3ZWM8
Research Area
Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity).

Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity).

Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway.
Biological Process
Cell differentiation Source: GO_Central
Innate immune response Source: InterPro
Natural killer cell proliferation Source: UniProtKB
NK T cell proliferation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
PML body. Accumulation into PML nuclear bodies is mediated by PML.
Involvement in disease
A chromosomal aberration involving ELF4 has been found in a case of acute myeloid leukemia (AML). Translocation t(X;21)(q25-26;q22) with ERG.

Liu, T., Yu, H., Zhang, Z., Xie, Y., Yang, L., & You, F. (2022). Intestinal ELF4 Deletion Exacerbates Alcoholic Liver Disease by Disrupting Gut Homeostasis. International journal of molecular sciences, 23(9), 4825.

Sun, G., Qiu, L., Yu, L., An, Y., Ding, Y., Zhou, L., ... & Du, H. (2022). Loss of function mutation in ELF4 causes autoinflammatory and immunodeficiency disease in human. Journal of Clinical Immunology, 1-13.

Kosti, A., Chiou, J., Guardia, G. D., Lei, X., Balinda, H., Landry, T., ... & Penalva, L. O. (2022). ELF4 is a critical component of a miRNA-transcription factor network and is a bridge regulator of glioblastoma receptor signaling and lipid dynamics. Neuro-oncology.

Sze, K. M. F., Ho, D. W. H., Chiu, Y. T., Tsui, Y. M., Chan, L. K., Lee, J. M. F., ... & Ng, I. O. L. (2021). Hepatitis B Virus–Telomerase Reverse Transcriptase Promoter Integration Harnesses Host ELF4, Resulting in Telomerase Reverse Transcriptase Gene Transcription in Hepatocellular Carcinoma. Hepatology, 73(1), 23-40.

Gong, R., Li, Z. Q., Fu, K., Ma, C., Wang, W., & Chen, J. C. (2021). Long noncoding RNA PVT1 promotes stemness and temozolomide resistance through miR-365/ELF4/SOX2 axis in glioma. Experimental Neurobiology, 30(3), 244.

Zhao, H., Xu, D., Tian, T., Kong, F., Lin, K., Gan, S., ... & Li, G. (2021). Molecular and functional dissection of EARLY-FLOWERING 3 (ELF3) and ELF4 in Arabidopsis. Plant Science, 303, 110786.

Tyler, P. M., Bucklin, M. L., Zhao, M., Maher, T. J., Rice, A. J., Ji, W., ... & Lucas, C. L. (2021). Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation. Nature immunology, 22(9), 1118-1126.

Kafita, D., Daka, V., Nkhoma, P., Zulu, M., Zulu, E., Tembo, R., ... & Munsaka, S. (2021). High ELF4 expression in human cancers is associated with worse disease outcomes and increased resistance to anticancer drugs. Plos one, 16(4), e0248984.

Chen, W. W., Takahashi, N., Hirata, Y., Ronald, J., Porco, S., Davis, S. J., ... & Mas, P. (2020). A mobile ELF4 delivers circadian temperature information from shoots to roots. Nature plants, 6(4), 416-426.

Kosti, A., Du, L., Shivram, H., Qiao, M., Burns, S., Garcia, J. G., ... & Penalva, L. O. (2020). ELF4 Is a Target of miR-124 and Promotes Neuroblastoma Proliferation and Undifferentiated StatemiR-124 Differentiates Neuroblastoma through ELF4. Molecular Cancer Research, 18(1), 68-78.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-ELF4 Recombinant Antibody (CBFYE-0775) (CAT#: V2LY-0825-LY70)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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