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Mouse Anti-ENC1 (AA 17-98) Recombinant Antibody (CBFYE-0212) (CBMAB-E0460-FY)

This product is mouse antibody that recognizes ENC1. The antibody CBFYE-0212 can be used for immunoassay techniques such as: ELISA, WB.
See all ENC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0212
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 17-98

Target

Full Name
ectodermal-neural cortex (with BTB-like domain)
Introduction
This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Entrez Gene ID
8507
UniProt ID
O14682
Alternative Names
Ectodermal-Neural Cortex 1; Ectodermal-Neural Cortex 1 (With BTB-Like Domain); Ectodermal-Neural Cortex 1 (With BTB Domain); Nuclear Matrix Protein NRP/B; Kelch-Like Family Member 37; P53-Induced Gene 10 Protein; Kelch-Like Protein 37; KLHL37; ENC-1; PIG10
Research Area
Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism.
Biological Process
Multicellular organism development Source: ProtInc
Negative regulation of translation Source: UniProtKB
Nervous system development Source: ProtInc
Positive regulation of neuron projection development Source: Ensembl
Proteasomal ubiquitin-independent protein catabolic process Source: UniProtKB
Protein ubiquitination Source: UniProtKB
Cellular Location
Nucleus matrix; Cytoskeleton; Cytoplasm
PTM
Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination.

Zhang, P., Zhao, F., Jia, K., & Liu, X. (2022). The LOXL1 antisense RNA 1 (LOXL1-AS1)/microRNA-423-5p (miR-423-5p)/ectodermal-neural cortex 1 (ENC1) axis promotes cervical cancer through the mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway. Bioengineered, 13(2), 2567-2584.

Mamoor, S. (2022). Differential expression of ENC1 in cancers of the breast.

Li, X., Zhao, H., Liu, J., & Tong, J. (2021). Long Non-coding RNA MIAT knockdown prevents the formation of intracranial aneurysm by downregulating ENC1 via MYC. Frontiers in physiology, 11, 572605.

Wu, C., Wang, X., Wu, X., & Chen, X. (2021). Ectodermal‑neural cortex 1 affects the biological function of lung cancer through the MAPK pathway. International Journal of Molecular Medicine, 47(5), 1-12.

Mamoor, S. (2021). Differential expression of ectodermal-neural cortex 1 in human epithelial ovarian cancer.

Li, L., Wang, N., Zhu, M., Xiong, Y., Wang, F., Guo, G., ... & Gu, Y. (2021). Aberrant super-enhancer-driven oncogene ENC1 promotes the radio-resistance of breast carcinoma. Cell death & disease, 12(8), 1-13.

Cui, Y., Yang, J., Bai, Y., Li, Q., Yao, Y., Liu, C., ... & Zhang, Y. (2021). ENC1 facilitates colorectal carcinoma tumorigenesis and metastasis via JAK2/STAT5/AKT axis-mediated epithelial mesenchymal transition and stemness. Frontiers in cell and developmental biology, 9, 616887.

Zhou, Y., Tang, X., Niu, L., Liu, Y., Wang, B., & He, J. (2020). Ectodermal‐neural cortex 1 as a novel biomarker predicts poor prognosis and induces metastasis in breast cancer by promoting Wnt/β‐catenin pathway. Journal of cellular and molecular medicine, 24(15), 8826-8835.

Fan, S., Wang, Y., Sheng, N., Xie, Y., Lu, J., Zhang, Z., ... & Zheng, Y. (2019). Low expression of ENC1 predicts a favorable prognosis in patients with ovarian cancer. Journal of Cellular Biochemistry, 120(1), 861-871.

Pereira, T. F. (2018). Role of Ectodermal-neural cortex 1 protein in human glioma progression, identification of a peptide internalized by human glioblastoma cells and development of an alternative method to generate growth curves of adherent cultures (Doctoral dissertation, Universidade de São Paulo).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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