Rabbit Anti-EPDR1 Recombinant Antibody (CBFYE-0955) (V2LY-0825-LY396)

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Basic Information

Host Animal
Rabbit
Clone
CBFYE-0955
Application
ELISA
Immunogen
Recombinant Human EPDR1 Protein.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Ependymin Related 1
Entrez Gene ID
UniProt ID
Research Area
Binds anionic lipids and gangliosides at acidic pH.
Biological Process
Cell-matrix adhesion Source: InterPro
Myofibroblast contraction Source: UniProtKB
Cellular Location
Secreted; Lysosome lumen. Lysosomal and also secreted.
PTM
N-glycosylated; the glycan contains mannose-6-phosphate moieties.By similarity

Ahmed, T., Flores, P. C., Pan, C. C., Ortiz, H. R., Lee, Y. S., Langlais, P. R., ... & Lee, N. Y. (2022). EPDR1 is a noncanonical effector of insulin-mediated angiogenesis regulated by an endothelial-specific TGF-β receptor complex. Journal of Biological Chemistry, 298(9).

El-Masry, O. S., Alamri, A. M., Alzahrani, F., & Alsamman, K. (2022). ADAMTS14, ARHGAP22, and EPDR1 as potential novel targets in acute myeloid leukaemia. Heliyon, 8(3), e09065.

Yang, Y., Zhang, H., Liu, Z., Zhao, F., & Liang, G. (2021). EPDR1 is related to stages and metastasize in bladder cancer and can be used as a prognostic biomarker. BMC urology, 21(1), 1-12.

Liu, X., Liu, C., Zhang, A., Wang, Q., Ge, J., Li, Q., & Xiao, J. (2021). Long non-coding RNA SDCBP2-AS1 delays the progression of ovarian cancer via microRNA-100-5p-targeted EPDR1. World Journal of Surgical Oncology, 19(1), 1-9.

Zhao, Z., Wang, Z., Wang, P., Liu, S., Li, Y., & Yang, X. (2021). EPDR1, Which Is Negatively Regulated by miR-429, Suppresses Epithelial Ovarian Cancer Progression via PI3K/AKT Signaling Pathway. Frontiers in oncology, 11, 751567-751567.

Gimeno-Valiente, F., Riffo-Campos, Á. L., Ayala, G., Tarazona, N., Gambardella, V., Rodríguez, F. M., ... & Castillo, J. (2020). EPDR1 up-regulation in human colorectal cancer is related to staging and favours cell proliferation and invasiveness. Scientific reports, 10(1), 1-14.

Chen, R., & Zhang, Y. (2020). EPDR1 correlates with immune cell infiltration in hepatocellular carcinoma and can be used as a prognostic biomarker. Journal of cellular and molecular medicine, 24(20), 12107-12118.

Deshmukh, A. S., Peijs, L., Beaudry, J. L., Jespersen, N. Z., Nielsen, C. H., Ma, T., ... & Scheele, C. (2019). Proteomics-based comparative mapping of the secretomes of human brown and white adipocytes reveals EPDR1 as a novel batokine. Cell metabolism, 30(5), 963-975.

Wei, Y., Xiong, Z. J., Li, J., Zou, C., Cairo, C. W., Klassen, J. S., & Privé, G. G. (2019). Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters. Communications biology, 2(1), 1-13.

Chu, C. H., Chang, S. C., Wang, H. H., Yang, S. H., Lai, K. C., & Lee, T. C. (2018). Prognostic values of EPDR1 hypermethylation and its inhibitory function on tumor invasion in colorectal cancer. Cancers, 10(10), 393.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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