Mouse Anti-EPHA7 Recombinant Antibody (CBFYE-0996) (V2LY-0825-LY451)

Name: Mouse Anti-EPHA7 Recombinant Antibody (CBFYE-0996)
SKU: V2LY-0825-LY451
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYE-0996

Application

WB, ELISA, IHC

Immunogen

Purified recombinant fragment of NCOA3 (aa 1-200) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
ELISA	1:10,000
WB	1:500-1:2,000
IHC	1:200-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

EPH Receptor A7

Entrez Gene ID

2045

UniProt ID

Q15375

Research Area

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

Biological Process

Apoptotic process Source: UniProtKB-KW
Axon guidance Source: GO_Central
Brain development Source: UniProtKB
Branching morphogenesis of a nerve Source: UniProtKB
Ephrin receptor signaling pathway Source: UniProtKB
Negative chemotaxis Source: UniProtKB
Negative regulation of collateral sprouting Source: Ensembl
Negative regulation of synapse assembly Source: Ensembl
Nephric duct morphogenesis Source: Ensembl
Phosphorylation Source: UniProtKB
Positive regulation of kinase activity Source: GO_Central
Positive regulation of neuron apoptotic process Source: UniProtKB
Positive regulation of protein phosphorylation Source: Ensembl
Regulation of cell-cell adhesion Source: UniProtKB
Regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Regulation of ERK1 and ERK2 cascade Source: UniProtKB
Regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Regulation of postsynapse organization Source: Ensembl
Regulation of protein autophosphorylation Source: UniProtKB
Retinal ganglion cell axon guidance Source: Ensembl
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 28-555
Helical: 556-576
Cytoplasmic: 577-998

PTM

Phosphorylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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