Rat Recombinant EphA7 protein, hFc Tag (V2LY-0526-LY9355)

Name: Rat Recombinant EphA7 protein, hFc Tag
SKU: V2LY-0526-LY9355
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Rat

Tag

hFc Tag

Protein Construction

This product is Rat Recombinant EphA7 protein, hFc Tag consist of Amino Acid: 1-539 and predicts a molecular mass of 58.9 kDa.

Molecule Mass

58.9 kDa

Sequence

Amino Acid: 1-539

Species

Rat

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

EPH Receptor A7

Research Area

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

Biological Process

Apoptotic process Source: UniProtKB-KW
Axon guidance Source: GO_Central
Brain development Source: UniProtKB
Branching morphogenesis of a nerve Source: UniProtKB
Ephrin receptor signaling pathway Source: UniProtKB
Negative chemotaxis Source: UniProtKB
Negative regulation of collateral sprouting Source: Ensembl
Negative regulation of synapse assembly Source: Ensembl
Nephric duct morphogenesis Source: Ensembl
Phosphorylation Source: UniProtKB
Positive regulation of kinase activity Source: GO_Central
Positive regulation of neuron apoptotic process Source: UniProtKB
Positive regulation of protein phosphorylation Source: Ensembl
Regulation of cell-cell adhesion Source: UniProtKB
Regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Regulation of ERK1 and ERK2 cascade Source: UniProtKB
Regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Regulation of postsynapse organization Source: Ensembl
Regulation of protein autophosphorylation Source: UniProtKB
Retinal ganglion cell axon guidance Source: Ensembl
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 28-555
Helical: 556-576
Cytoplasmic: 577-998

PTM

Phosphorylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant EphA7 protein, GST Tag (CAT#: V2LY-0526-LY3891)

Human Recombinant EphA7 protein, His Tag (CAT#: V2LY-0526-LY3892)

Mouse Recombinant EPHA7, Active protein, GST Tag (CAT#: V2LY-0526-LY8247)

Mouse Recombinant EPHA7 protein, His Tag (CAT#: V2LY-0526-LY8248)

Mouse Epha7 ELISA Kit (CAT#: V2LY-0626-LY2340)

Rat Recombinant EphA7 protein, His Tag (CAT#: V2LY-0526-LY9356)

Related Products

Mouse Recombinant EPHA7 protein, His Tag (CAT#: V2LY-0526-LY8248)

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Mouse Anti-EPHA7 Recombinant Antibody (CBFYE-0996) (CAT#: V2LY-0825-LY451)

Mouse Anti-EPHA7 Recombinant Antibody (CBT486) (CAT#: V2LY-0625-LY3486)

Rat Anti-EPHA7 Recombinant Antibody (1174) (CAT#: V2LY-0825-LY447)

Rabbit Anti-EPHA7 Recombinant Antibody (CP0616) (CAT#: V2LY-0825-LY452)

Mouse Anti-EPHA7 Recombinant Antibody (E1493) (CAT#: V2LY-0825-LY449)

Rat Recombinant EphA7 protein, His Tag (CAT#: V2LY-0526-LY9356)

Human Recombinant EphA7 protein, GST Tag (CAT#: V2LY-0526-LY3891)

Mouse Recombinant EPHA7, Active protein, GST Tag (CAT#: V2LY-0526-LY8247)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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