Rat Anti-EPHB6 Recombinant Antibody (17) (CBMAB-1171-YC)

Name: Rat Anti-EPHB6 Recombinant Antibody (17)
SKU: CBMAB-1171-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rat

Clone

Application

Immunogen

Recombinant mouse EphB6 (Leu33-Ser587).

Host Species

Rat

Specificity

Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, trehalose

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

EPH Receptor B6

Introduction

EPHB6 is a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. EPHB6 can influence cell adhesion and migration. EPHB6 may suppress tumor invasion and metastasis.

Entrez Gene ID

13848

UniProt ID

O08644

Alternative Names

HEP

Research Area

Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.

Biological Process

Axon guidance Source: GO_Central
Central nervous system projection neuron axonogenesis Source: GO_Central
Positive regulation of kinase activity Source: GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central

Cellular Location

Membrane
Isoform 3: Secreted

Topology

Extracellular: 32-594
Helical: 595-615
Cytoplasmic: 616-1021

PTM

Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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