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Rat Anti-EPHB6 Monoclonal Antibody (RM0057-9B17) (CBMAB-1171-YC)

Provided herein is a rat monoclonal antibody against Mouse EPHB6. The antibody, clone RM0057-9B17, can be used for immunoassay techniques, such as IHC-P and WB.
See all EPHB6 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
RM0057-9B17
Antibody Isotype
IgG2
Application
IHC-P, WB

Basic Information

Immunogen
Recombinant mouse Eph receptor B6 extracellular domain
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
EPH Receptor B6
Introduction
EPHB6 is a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. EPHB6 can influence cell adhesion and migration. EPHB6 may suppress tumor invasion and metastasis.
Entrez Gene ID
13848
UniProt ID
O08644
Alternative Names
HEP
Research Area
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
Biological Process
Axon guidance Source: GO_Central
Central nervous system projection neuron axonogenesis Source: GO_Central
Positive regulation of kinase activity Source: GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Cellular Location
Membrane
Isoform 3: Secreted
Topology
Extracellular: 32-594
Helical: 595-615
Cytoplasmic: 616-1021
PTM
Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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