EPHB6
This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Full Name
EPH Receptor B6
Research Area
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
Biological Process
Axon guidance Source: GO_Central
Central nervous system projection neuron axonogenesis Source: GO_Central
Positive regulation of kinase activity Source: GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Central nervous system projection neuron axonogenesis Source: GO_Central
Positive regulation of kinase activity Source: GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Cellular Location
Membrane
Isoform 3: Secreted
Isoform 3: Secreted
Topology
Extracellular: 32-594
Helical: 595-615
Cytoplasmic: 616-1021
Helical: 595-615
Cytoplasmic: 616-1021
PTM
Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.
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Anti-EPHB6 antibodies
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CompareTarget: EPHB6
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 17
Application*: WB
Target: EPHB6
Sensitivity: 0.015 ng/mL
Detection Range: 0.03-9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: EphB6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-587
Tag: His Tag
Target: EphB6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-579
Tag: His Tag
Target: EphB6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-579
Tag: hFc Tag
Target: EphB6
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 617-end
Tag: GST Tag
Target: EPHB6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-591
Tag: hFc Tag
Target: EPHB6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-1032
Application*: E
Target: EPHB6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-1031
Application*: E
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYE-1029
Application*: E
Target: EPHB6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-1026
Application*: E
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: E1540
Application*: E, IP, WB, IF, P
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 2A6B9
Application*: E, WB, IP
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT494
Application*: WB, P, IF, E
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT495
Application*: WB, P, IF, E
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2870
Application*: IH
Target: EphB6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3440
Application*: WB, IH
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 5H6
Application*: WB, E
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 5D8
Application*: WB, E, IH
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3B6
Application*: WB, E
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBFYH-0156
Application*: WB
Target: EPHB6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-1030
Application*: E
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0101
Application*: F
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 12
Application*: E, IP, WB, IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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