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EPHB6

This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Full Name
EPH Receptor B6
Research Area
Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
Biological Process
Axon guidance Source: GO_Central
Central nervous system projection neuron axonogenesis Source: GO_Central
Positive regulation of kinase activity Source: GO_Central
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Cellular Location
Membrane
Isoform 3: Secreted
Topology
Extracellular: 32-594
Helical: 595-615
Cytoplasmic: 616-1021
PTM
Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion.

Anti-EPHB6 antibodies

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Mouse Anti-EPHB6 Recombinant Antibody (4A9C4F2) (CBMAB-E1540-FY)

Datasheet SDS
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4A9C4F2
Application*: E

Mouse Anti-EPHB6 Recombinant Antibody (8E7H12) (CBMAB-E1537-FY)

Datasheet SDS
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8E7H12
Application*: E, IH, P, WB

Mouse Anti-EPHB6 (AA 17-579) Recombinant Antibody (CBFYE-0101) (CBMAB-E0208-FY)

Datasheet SDS
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0101
Application*: F, MC

Mouse Anti-EPHB6 (AA 23-122) Recombinant Antibody (CBFYE-1029) (CBMAB-E1539-FY)

Datasheet SDS
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-1029
Application*: E, IH, WB

Rabbit Anti-EPHB6 (AA 1-579) Recombinant Antibody (CBFYE-1030) (CBMAB-E1541-FY)

Datasheet SDS
Target: EPHB6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-1030
Application*: E

Mouse Anti-EPHB6 Recombinant Antibody (CBFYE-1033) (CBMAB-E1544-FY)

Datasheet SDS
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-1033
Application*: F

Mouse Anti-EPHB6 (AA 23-122) Recombinant Antibody (CBFYH-0156) (CBMAB-H1023-FY)

Datasheet SDS
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-0156
Application*: E, P, WB

Mouse Anti-EPHB6 Recombinant Antibody (5D8) (CBMAB-A2663-LY)

Datasheet SDS
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5D8
Application*: WB, E

Mouse Anti-EPHB6 Recombinant Antibody (5H6) (CBMAB-A2664-LY)

Datasheet SDS
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 5H6
Application*: WB, E

Mouse Anti-EPHB6 Recombinant Antibody (2A6B9) (CBMAB-E1536-FY)

Datasheet SDS
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A6B9
Application*: E, WB, P, IF, F

Mouse Anti-EPHB6 (AA 17-579) Recombinant Antibody (CBFYE-1026) (CBMAB-E1534-FY)

Datasheet SDS
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBFYE-1026
Application*: WB

Mouse Anti-EPHB6 (AA 601-750) Recombinant Antibody (CBFYE-1031) (CBMAB-E1542-FY)

Datasheet SDS
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-1031
Application*: E, IH, WB

Mouse Anti-EPHB6 Recombinant Antibody (CBFYE-1032) (CBMAB-E1543-FY)

Datasheet SDS
Target: EPHB6
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBFYE-1032
Application*: WB, IP, IF, E

Mouse Anti-EPHB6 Recombinant Antibody (3B6) (CBMAB-A2662-LY)

Datasheet SDS
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 3B6
Application*: WB, E

Mouse Anti-EPHB6 Recombinant Antibody (CBFYH-3411) (CBMAB-H3956-FY)

Datasheet SDS
Target: EPHB6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-3411
Application*: E, WB, P

Rat Anti-EPHB6 Monoclonal Antibody (RM0057-9B17) (CBMAB-1171-YC)

Datasheet SDS
Target: EPHB6
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: RM0057-9B17
Application*: P, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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