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Mouse Anti-FABP7 Monoclonal Antibody (7D2) (CBMAB-1230-YC)

Provided herein is a mouse monoclonal antibody against Human FABP7. The antibody, clone 7D2, can be used for immunoassay techniques, such as WB.
See all FABP7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
7D2
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
FABP7
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fatty Acid Binding Protein 7
Introduction
FABP7 is a small, highly conserved cytoplasmic protein that bind long-chain fatty acids and other hydrophobic ligands. FABP7 is important in the establishment of the radial glial fiber in the developing brain.
Entrez Gene ID
2173
UniProt ID
O15540
Alternative Names
MRG; BLBP; FABPB; B-FABP
Research Area
B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity).
Biological Process
Epithelial cell proliferation Source: Ensembl
Negative regulation of cell population proliferation Source: ProtInc
Nervous system development Source: ProtInc
Cellular Location
Cytoplasm

Zeng, F., Luo, L., Song, M., & Li, D. (2022). Silencing of circular RNA PUM1 inhibits clear cell renal cell carcinoma progression through the miR-340-5p/FABP7 axis. Journal of Receptors and Signal Transduction, 42(2), 141-150.

Nowowiejska, J., Baran, A., Hermanowicz, J. M., Sieklucka, B., Krahel, J. A., Kiluk, P., ... & Flisiak, I. (2022). Fatty Acid-Binding Protein 7 (FABP-7), Glutamic Acid and Neurofilament Light Chain (NFL) as Potential Markers of Neurodegenerative Disorders in Psoriatic Patients—A Pilot Study. Journal of clinical medicine, 11(9), 2430.

Umaru, B. A., Kagawa, Y., Shil, S. K., Arakawa, N., Pan, Y., Miyazaki, H., ... & Owada, Y. (2021). Ligand bound fatty acid binding protein 7 (FABP7) drives melanoma cell proliferation via modulation of wnt/β-catenin signaling. Pharmaceutical research, 38(3), 479-490.

Choi, W. S., Xu, X., Goruk, S., Wang, Y., Patel, S., Chow, M., ... & Godbout, R. (2021). FABP7 Facilitates Uptake of Docosahexaenoic Acid in Glioblastoma Neural Stem-like Cells. Nutrients, 13(8), 2664.

Chen, J., Liu, X., Zhang, S., Chen, J., Sun, H., Zhang, L., & Zhang, Q. (2020). Molecular mechanism with regard to the binding selectivity of inhibitors toward FABP5 and FABP7 explored by multiple short molecular dynamics simulations and free energy analyses. Physical Chemistry Chemical Physics, 22(4), 2262-2275.

Killoy, K. M., Harlan, B. A., Pehar, M., & Vargas, M. R. (2020). FABP7 upregulation induces a neurotoxic phenotype in astrocytes. Glia, 68(12), 2693-2704.

Kagawa, Y., Umaru, B. A., Ariful, I., Shil, S. K., Miyazaki, H., Yamamoto, Y., ... & Owada, Y. (2019). Role of FABP7 in tumor cell signaling. Advances in biological regulation, 71, 206-218.

Cordero, A., Kanojia, D., Miska, J., Panek, W. K., Xiao, A., Han, Y., ... & Lesniak, M. S. (2019). FABP7 is a key metabolic regulator in HER2+ breast cancer brain metastasis. Oncogene, 38(37), 6445-6460.

Islam, A., Kagawa, Y., Miyazaki, H., Shil, S. K., Umaru, B. A., Yasumoto, Y., ... & Owada, Y. (2019). FABP7 protects astrocytes against ROS toxicity via lipid droplet formation. Molecular Neurobiology, 56(8), 5763-5779.

Yasumoto, Y., Miyazaki, H., Ogata, M., Kagawa, Y., Yamamoto, Y., Islam, A., ... & Owada, Y. (2018). Glial fatty acid-binding protein 7 (FABP7) regulates neuronal leptin sensitivity in the hypothalamic arcuate nucleus. Molecular Neurobiology, 55(12), 9016-9028.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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