Mouse Anti-FAM19A1 Recombinant Antibody (CBYJT-1274) (CBMAB-T0289-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to FAM19A1 (Family With Sequence Similarity 19 Member A1, C-C Motif Chemokine Like). The antibody can be used for immunoassay techniques, such as WB.
See all FAM19A1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYJT-1274

Antibody Isotype

IgG1

Application

Basic Information

Immunogen

E. coli-derived recombinant human TAFA1/FAM19A1, Ser26-Thr133, Accession # Q7Z5A9

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, Trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 26-133

Target

Full Name

Family With Sequence Similarity 19 Member A1, C-C Motif Chemokine Like

Introduction

FAM19A1 is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to play a role as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells.

Entrez Gene ID

407738

UniProt ID

Q7Z5A9

Alternative Names

Family With Sequence Similarity 19 Member A1, C-C Motif Chemokine Like; Family With Sequence Similarity 19 (Chemokine (C-C Motif)-Like), Member A1; Chemokine-Like Protein TAFA-1; TAFA1; Protein FAM19A1; TAFA-1

Research Area

Regulatory factor which is ligand for CMKLR2 and is involved in the modulation of neural stem-cell proliferation and differentiation.

Biological Process

Neuroblast differentiation Source: UniProtKB
Regulation of neuroblast proliferation Source: UniProtKB
Regulation of signaling receptor activity Source: UniProtKB

Cellular Location

Secreted

References

Zhang, Y. F., Li, X. X., Cao, X. L., Ji, C. C., Gao, X. Y., Gao, D., ... & Zheng, M. H. (2022). MicroRNA-582-5p Contributes to the Maintenance of Neural Stem Cells Through Inhibiting Secretory Protein FAM19A1. Frontiers in Cellular Neuroscience, 259.

Yong, H. J., Hwang, J. I., & Seong, J. Y. (2021). Alterations in dendritic spine maturation and neurite development mediated by FAM19A1. Cells, 10(8), 1868.

Yong, H. J., Ha, N., Cho, E. B., Yun, S., Kim, H., Hwang, J. I., & Seong, J. Y. (2020). The unique expression profile of FAM19A1 in the mouse brain and its association with hyperactivity, long-term memory and fear acquisition. Scientific reports, 10(1), 1-14.

Lei, X., Liu, L., Terrillion, C. E., Karuppagounder, S. S., Cisternas, P., Lay, M., ... & Wong, G. W. (2019). FAM19A1, a brain‐enriched and metabolically responsive neurokine, regulates food intake patterns and mouse behaviors. The FASEB Journal, 33(12), 14734-14747.

Zheng, C., Chen, D., Zhang, Y., Bai, Y., Huang, S., Zheng, D., ... & Wang, Y. (2018). FAM19A1 is a new ligand for GPR1 that modulates neural stem‐cell proliferation and differentiation. The FASEB Journal, 32(11), 5874-5890.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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