Rabbit Anti-FASN Recombinant Antibody (CBXF-1248) (V2LY-0925-LY210)

Name: Rabbit Anti-FASN Recombinant Antibody (CBXF-1248)
SKU: V2LY-0925-LY210
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXF-1248

Application

WB, IHC-P, IF

Immunogen

Recombinant fragmemt of human Fatty Acid Synthase.

Host Species

Rabbit

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

2 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fatty Acid Synthase

Entrez Gene ID

Human	2194
Mouse	14104
Rat	50671

UniProt ID

Human	P49327
Mouse	P19096
Rat	P12785

Research Area

Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

Biological Process

Acetyl-CoA metabolic process Source: Ensembl
Cellular response to interleukin-4 Source: Ensembl
Establishment of endothelial intestinal barrier Source: Ensembl
Ether lipid biosynthetic process Source: Ensembl
Fatty acid biosynthetic process Source: UniProtKB-UniPathway
Fatty acid metabolic process Source: ProtInc
Glandular epithelial cell development Source: Ensembl
Mammary gland development Source: Ensembl
Monocyte differentiation Source: Ensembl
Neutrophil differentiation Source: Ensembl
Osteoblast differentiation Source: UniProtKB

Cellular Location

Cytoplasm; Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

PTM

S-nitrosylation of Fatty acid synthase at cysteine residues Cys-1471 or Cys-2091 is important for the enzyme dimerization. In adipocytes, S-nitrosylation of Fatty acid synthase occurs under physiological conditions and gradually increases during adipogenesis.

Grunt, T. W., Lemberger, L., Colomer, R., López− Rodríguez, M. L., & Wagner, R. (2021). The pharmacological or genetic blockade of endogenous de novo fatty acid synthesis does not increase the uptake of exogenous lipids in ovarian cancer cells. Frontiers in oncology, 11, 610885.

Fhu, C. W., & Ali, A. (2020). Fatty acid synthase: an emerging target in cancer. Molecules, 25(17), 3935.

Che, L., Chi, W., Qiao, Y., Zhang, J., Song, X., Liu, Y., ... & Chen, L. (2020). Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans. Gut, 69(1), 177-186.

Zhang, N., Zhao, H., & Zhang, L. (2019). Fatty acid synthase promotes the palmitoylation of chikungunya virus nsP1. Journal of virology, 93(3), e01747-18.

Bruning, U., Morales-Rodriguez, F., Kalucka, J., Goveia, J., Taverna, F., Queiroz, K. C., ... & Carmeliet, P. (2018). Impairment of angiogenesis by fatty acid synthase inhibition involves mTOR malonylation. Cell metabolism, 28(6), 866-880.

Jiang, L., Fang, X., Wang, H., Li, D., & Wang, X. (2018). Ovarian cancer-intrinsic fatty acid synthase prevents anti-tumor immunity by disrupting tumor-infiltrating dendritic cells. Frontiers in immunology, 9, 2927.

Zaytseva, Y. Y., Rychahou, P. G., Le, A. T., Scott, T. L., Flight, R. M., Kim, J. T., ... & Evers, M. (2018). Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer. Oncotarget, 9(37), 24787.

Jung, M. Y., Kang, J. H., Hernandez, D. M., Yin, X., Andrianifahanana, M., Wang, Y., ... & Leof, E. B. (2018). Fatty acid synthase is required for profibrotic TGF-β signaling. The FASEB Journal, 32(7), 3803.

Carroll, R. G., Zasłona, Z., Galván-Peña, S., Koppe, E. L., Sévin, D. C., Angiari, S., ... & O’Neill, L. A. (2018). An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation. Journal of Biological Chemistry, 293(15), 5509-5521.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

FASN Matched Antibody Pair (412) (CAT#: APMAB-412LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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