FASN Matched Antibody Pair (412) (APMAB-412LY)

Name: FASN Matched Antibody Pair (412)
SKU: APMAB-412LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-FASN polyclonal antibody, 100 ug

Detection Antibody

Anti-FASN Mouse monoclonal, IgG1 antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]

Alternative Names

Fatty Acid Synthase; Short Chain Dehydrogenase/Reductase Family 27X, Member 1; FAS; EC 2.3.1.85; EC 6.3.3.1; EC 2.3.1; SDR27X1; OA-519;

Entrez Gene ID

2194

UniProt ID

P49327

More Infomation

Grunt, T. W., Lemberger, L., Colomer, R., López− Rodríguez, M. L., & Wagner, R. (2021). The pharmacological or genetic blockade of endogenous de novo fatty acid synthesis does not increase the uptake of exogenous lipids in ovarian cancer cells. Frontiers in oncology, 11, 610885.

Fhu, C. W., & Ali, A. (2020). Fatty acid synthase: an emerging target in cancer. Molecules, 25(17), 3935.

Che, L., Chi, W., Qiao, Y., Zhang, J., Song, X., Liu, Y., ... & Chen, L. (2020). Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans. Gut, 69(1), 177-186.

Zhang, N., Zhao, H., & Zhang, L. (2019). Fatty acid synthase promotes the palmitoylation of chikungunya virus nsP1. Journal of virology, 93(3), e01747-18.

Bruning, U., Morales-Rodriguez, F., Kalucka, J., Goveia, J., Taverna, F., Queiroz, K. C., ... & Carmeliet, P. (2018). Impairment of angiogenesis by fatty acid synthase inhibition involves mTOR malonylation. Cell metabolism, 28(6), 866-880.

Jiang, L., Fang, X., Wang, H., Li, D., & Wang, X. (2018). Ovarian cancer-intrinsic fatty acid synthase prevents anti-tumor immunity by disrupting tumor-infiltrating dendritic cells. Frontiers in immunology, 9, 2927.

Zaytseva, Y. Y., Rychahou, P. G., Le, A. T., Scott, T. L., Flight, R. M., Kim, J. T., ... & Evers, M. (2018). Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer. Oncotarget, 9(37), 24787.

Jung, M. Y., Kang, J. H., Hernandez, D. M., Yin, X., Andrianifahanana, M., Wang, Y., ... & Leof, E. B. (2018). Fatty acid synthase is required for profibrotic TGF-β signaling. The FASEB Journal, 32(7), 3803.

Carroll, R. G., Zasłona, Z., Galván-Peña, S., Koppe, E. L., Sévin, D. C., Angiari, S., ... & O’Neill, L. A. (2018). An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation. Journal of Biological Chemistry, 293(15), 5509-5521.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant FASN protein, His Tag (CAT#: V2LY-0526-LY4028)

Mouse Recombinant FASN protein, His Tag (CAT#: V2LY-0526-LY8300)

Rat Fasn ELISA Kit (CAT#: V2LY-0626-LY2205)

Human FASN ELISA Kit (CAT#: V2LY-0626-LY3876)

Mouse Fasn ELISA Kit (CAT#: V2LY-0626-LY4118)

Related Products

Mouse Fasn ELISA Kit (CAT#: V2LY-0626-LY4118)

Rat Fasn ELISA Kit (CAT#: V2LY-0626-LY2205)

Mouse Anti-FASN Recombinant Antibody (CBXF-0343) (CAT#: CBMAB-F1684-CQ)

Rabbit Anti-FASN Recombinant Antibody (
2A5) (CAT#: V2LY-0725-LY1093)

Mouse Anti-FASN Recombinant Antibody (CBXF-2574) (CAT#: CBMAB-F3021-CQ)

Mouse Recombinant FASN protein, His Tag (CAT#: V2LY-0526-LY8300)

Rabbit Anti-FASN Recombinant Antibody (CBXF-1248) (CAT#: V2LY-0925-LY210)

Mouse Anti-FASN Recombinant Antibody (CBXF-0335) (CAT#: V2LY-0925-LY211)

Rabbit Anti-FASN Recombinant Antibody (CBXF-1476) (CAT#: V2LY-0925-LY227)

Mouse Anti-FASN Recombinant Antibody (CBXF-0339) (CAT#: CBMAB-F2213-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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