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Mouse Anti-FBXL7 (AA 392-490) Recombinant Antibody (CBXF-0389) (CBMAB-F0352-CQ)

This product is a mouse antibody that recognizes FBXL7 (AA 392-490). The antibody CBXF-0389 can be used for immunoassay techniques such as: ELISA.
See all FBXL7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0389
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 392-490

Target

Full Name
F-box and leucine-rich repeat protein 7
Introduction
This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene.
Entrez Gene ID
23194
UniProt ID
Q9UJT9
Alternative Names
F-Box And Leucine Rich Repeat Protein 7; FBL6; FBL7; F-Box And Leucine-Rich Repeat Protein 7; F-Box/LRR-Repeat Protein 7; F-Box Protein FBL6/FBL7; F-Box Protein Fbl7; KIAA0840;
Research Area
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:25778398).

During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest (By similarity).

It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 (PubMed:25778398, PubMed:28218735).
Biological Process
Cell division Source: UniProtKB-KW
G2/M transition of mitotic cell cycle Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Protein polyubiquitination Source: UniProtKB
Protein ubiquitination Source: UniProtKB
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: UniProtKB
Cellular Location
Centrosome. Localizes to the centrosome during spindle formation.

Wang, Y., Shen, X., Gong, L., Zhao, Y., & Xiong, X. (2022). Functional characterization of FBXL7 as a novel player in human cancers. Cell Death Discovery, 8(1), 1-8.

Camuzi, D., Buexm, L. A., Lourenço, S. D. Q. C., Grazziotin, R., Guaraldi, S., Valverde, P., ... & Soares-Lima, S. C. (2022). FBXL7 body hypomethylation is frequent in tumors from the digestive and respiratory tracts and is associated with risk-factor exposure. International Journal of Molecular Sciences, 23(14), 7801.

Ni, J., Shen, L., Xu, L., Jin, Q., & Wang, G. (2021). 7-Ethoxyrosmanol alleviates hyperglycemia-induced vascular endothelial dysfunction by regulating FBXL7 expression. Journal of Bioenergetics and Biomembranes, 53(5), 553-560.

Moro, L., Simoneschi, D., Kurz, E., Arbini, A. A., Jang, S., Guaragnella, N., ... & Pagano, M. (2020). Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis. Nature cell biology, 22(9), 1130-1142.

Boone, P. M., Paterson, S., Mohajeri, K., Zhu, W., Genetti, C. A., Tai, D. J., ... & Rodan, L. H. (2020). Biallelic mutation of FBXL7 suggests a novel form of Hennekam syndrome. American Journal of Medical Genetics Part A, 182(1), 189-194.

Kong, S., Fang, Y., Wang, B., Cao, Y., He, R., & Zhao, Z. (2020). miR‐152‐5p suppresses glioma progression and tumorigenesis and potentiates temozolomide sensitivity by targeting FBXL7. Journal of Cellular and Molecular Medicine, 24(8), 4569-4579.

Moro, L., & Pagano, M. (2020). Epigenetic suppression of FBXL7 promotes metastasis. Molecular & Cellular Oncology, 7(6), 1833698.

Chiu, H. W., Chang, J. S., Lin, H. Y., Lee, H. H., Kuei, C. H., Lin, C. H., ... & Lin, Y. F. (2018). FBXL7 upregulation predicts a poor prognosis and associates with a possible mechanism for paclitaxel resistance in ovarian cancer. Journal of clinical medicine, 7(10), 330.

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For research use only. Not intended for any clinical use.

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