Mouse Anti-FBXL7 Recombinant Antibody (CBXF-0388) (V2LY-0925-LY407)

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Basic Information

Host Animal
Mouse
Clone
CBXF-0388
Application
ELISA, WB
Immunogen
FBXL7 (aa 392-489) partial recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
F-box and leucine-rich repeat protein 7
Entrez Gene ID
UniProt ID
Research Area
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:25778398).

During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest (By similarity).

It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 (PubMed:25778398, PubMed:28218735).
Biological Process
Cell division Source: UniProtKB-KW
G2/M transition of mitotic cell cycle Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Protein polyubiquitination Source: UniProtKB
Protein ubiquitination Source: UniProtKB
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Ubiquitin-dependent protein catabolic process Source: UniProtKB
Cellular Location
Centrosome. Localizes to the centrosome during spindle formation.

Wang, Y., Shen, X., Gong, L., Zhao, Y., & Xiong, X. (2022). Functional characterization of FBXL7 as a novel player in human cancers. Cell Death Discovery, 8(1), 1-8.

Camuzi, D., Buexm, L. A., Lourenço, S. D. Q. C., Grazziotin, R., Guaraldi, S., Valverde, P., ... & Soares-Lima, S. C. (2022). FBXL7 body hypomethylation is frequent in tumors from the digestive and respiratory tracts and is associated with risk-factor exposure. International Journal of Molecular Sciences, 23(14), 7801.

Ni, J., Shen, L., Xu, L., Jin, Q., & Wang, G. (2021). 7-Ethoxyrosmanol alleviates hyperglycemia-induced vascular endothelial dysfunction by regulating FBXL7 expression. Journal of Bioenergetics and Biomembranes, 53(5), 553-560.

Moro, L., Simoneschi, D., Kurz, E., Arbini, A. A., Jang, S., Guaragnella, N., ... & Pagano, M. (2020). Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis. Nature cell biology, 22(9), 1130-1142.

Boone, P. M., Paterson, S., Mohajeri, K., Zhu, W., Genetti, C. A., Tai, D. J., ... & Rodan, L. H. (2020). Biallelic mutation of FBXL7 suggests a novel form of Hennekam syndrome. American Journal of Medical Genetics Part A, 182(1), 189-194.

Kong, S., Fang, Y., Wang, B., Cao, Y., He, R., & Zhao, Z. (2020). miR‐152‐5p suppresses glioma progression and tumorigenesis and potentiates temozolomide sensitivity by targeting FBXL7. Journal of Cellular and Molecular Medicine, 24(8), 4569-4579.

Moro, L., & Pagano, M. (2020). Epigenetic suppression of FBXL7 promotes metastasis. Molecular & Cellular Oncology, 7(6), 1833698.

Chiu, H. W., Chang, J. S., Lin, H. Y., Lee, H. H., Kuei, C. H., Lin, C. H., ... & Lin, Y. F. (2018). FBXL7 upregulation predicts a poor prognosis and associates with a possible mechanism for paclitaxel resistance in ovarian cancer. Journal of clinical medicine, 7(10), 330.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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