Mouse Anti-FBXL8 Recombinant Antibody (CBXF-0391) (CBMAB-F0341-CQ)

Name: Mouse Anti-FBXL8 Recombinant Antibody (CBXF-0391)
SKU: CBMAB-F0341-CQ
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBXF-0391

Antibody Isotype

IgG1, κ

Application

ELISA

Basic Information

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

F-box and leucine-rich repeat protein 8

Introduction

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein.

Entrez Gene ID

55336

UniProt ID

Q96CD0

Alternative Names

F-Box And Leucine Rich Repeat Protein 8; F-Box Protein FBL8; FBL8; F-Box And Leucine-Rich Repeat Protein 8; F-Box/LRR-Repeat Protein 8;

Research Area

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Biological Process

Entrainment of circadian clock by photoperiod Source: GO_Central
G2/M transition of mitotic cell cycle Source: GO_Central
Regulation of cell cycle Source: GO_Central
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central

Cellular Location

Cytosol; Nucleus; SCF ubiquitin ligase complex

More Infomation

References

Yoshida, A., Choi, J., Jin, H. R., Li, Y., Bajpai, S., Qie, S., & Diehl, J. A. (2021). Fbxl8 suppresses lymphoma growth and hematopoietic transformation through degradation of cyclin D3. Oncogene, 40(2), 292-306.

Chang, S. C., Hsu, W., Su, E. C. Y., Hung, C. S., & Ding, J. L. (2020). Human FBXL8 is a novel E3 ligase which promotes BRCA metastasis by stimulating pro-tumorigenic cytokines and inhibiting tumor suppressors. Cancers, 12(8), 2210.

Mamoor, S. (2020). FBXL8 is differentially expressed and transcriptionally induced in MERS coronavirus infection.

Chang, S. C., Hsu, W., Su, E. C. Y., Hung, C. S., & Ding, J. L. (2020). Global RNA-seq identified FBXL8 as a novel E3 ligase which modulates tumor suppressors to promote BRCA advancement. medRxiv.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-FBXL8 Recombinant Antibody (2E1)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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