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Mouse Anti-FBXO28 (AA 191-290) Recombinant Antibody (CBXF-2901) (CBMAB-F3608-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2901
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
FBXO28 (NP_055991, 191aa-290aa) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 191-290

Target

Introduction
Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).
Entrez Gene ID
23219
UniProt ID
Q9NVF7
Alternative Names
F-Box Protein 28; Centromere Protein 30; CENP-30; F-Box Only Protein 28; KIAA0483; Fbx28;
Research Area
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
Biological Process
Protein polyubiquitination Source: GO_Central
Cellular Location
Kinetochore
More Infomation

Phillips, E., Balss, J., Bethke, F., Pusch, S., Christen, S., Hielscher, T., ... & Goidts, V. (2022). PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma. Oncogenesis, 11(1), 1-12.

Schneider, A. L., Myers, C. T., Muir, A. M., Calvert, S., Basinger, A., Perry, M. S., ... & Scheffer, I. E. (2021). FBXO28 causes developmental and epileptic encephalopathy with profound intellectual disability. Epilepsia, 62(1), e13-e21.

Cai, L., Liu, L., Li, L., & Jia, L. (2020). SCFFBXO28-mediated self-ubiquitination of FBXO28 promotes its degradation. Cellular Signalling, 65, 109440.

Yu, T., Wang, L., Zhao, C., Qian, B., Yao, C., He, F., ... & Qiu, W. (2019). Sublytic C5b‐9 induces proliferation of glomerular mesangial cells via ERK5/MZF1/RGC‐32 axis activated by FBXO28‐TRAF6 complex. Journal of cellular and molecular medicine, 23(8), 5654-5671.

Yanagishita, T., Yamamoto-Shimojima, K., Nakano, S., Sasaki, T., Shigematsu, H., Imai, K., & Yamamoto, T. (2019). Phenotypic features of 1q41q42 microdeletion including WDR26 and FBXO28 are clinically recognizable: the first case from Japan. Brain and Development, 41(5), 452-455.

Balak, C., Belnap, N., Ramsey, K., Joss, S., Devriendt, K., Naymik, M., ... & Narayanan, V. (2018). A novel FBXO28 frameshift mutation in a child with developmental delay, dysmorphic features, and intractable epilepsy: A second gene that may contribute to the 1q41‐q42 deletion phenotype. American Journal of Medical Genetics Part A, 176(7), 1549-1558.

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For research use only. Not intended for any clinical use.

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