Mouse Anti-FBXO28 Recombinant Antibody (3E5) (V2LY-0925-LY446)

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Basic Information

Host Animal
Mouse
Clone
3E5
Application
ELISA
Immunogen
FBXO28 (aa 191-290) partial recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
F-box protein 28
Entrez Gene ID
UniProt ID
Research Area
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
Biological Process
Protein polyubiquitination Source: GO_Central
Cellular Location
Kinetochore

Phillips, E., Balss, J., Bethke, F., Pusch, S., Christen, S., Hielscher, T., ... & Goidts, V. (2022). PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma. Oncogenesis, 11(1), 1-12.

Schneider, A. L., Myers, C. T., Muir, A. M., Calvert, S., Basinger, A., Perry, M. S., ... & Scheffer, I. E. (2021). FBXO28 causes developmental and epileptic encephalopathy with profound intellectual disability. Epilepsia, 62(1), e13-e21.

Cai, L., Liu, L., Li, L., & Jia, L. (2020). SCFFBXO28-mediated self-ubiquitination of FBXO28 promotes its degradation. Cellular Signalling, 65, 109440.

Yu, T., Wang, L., Zhao, C., Qian, B., Yao, C., He, F., ... & Qiu, W. (2019). Sublytic C5b‐9 induces proliferation of glomerular mesangial cells via ERK5/MZF1/RGC‐32 axis activated by FBXO28‐TRAF6 complex. Journal of cellular and molecular medicine, 23(8), 5654-5671.

Yanagishita, T., Yamamoto-Shimojima, K., Nakano, S., Sasaki, T., Shigematsu, H., Imai, K., & Yamamoto, T. (2019). Phenotypic features of 1q41q42 microdeletion including WDR26 and FBXO28 are clinically recognizable: the first case from Japan. Brain and Development, 41(5), 452-455.

Balak, C., Belnap, N., Ramsey, K., Joss, S., Devriendt, K., Naymik, M., ... & Narayanan, V. (2018). A novel FBXO28 frameshift mutation in a child with developmental delay, dysmorphic features, and intractable epilepsy: A second gene that may contribute to the 1q41‐q42 deletion phenotype. American Journal of Medical Genetics Part A, 176(7), 1549-1558.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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