Rat Anti-FGFRL1 Recombinant Antibody (CBXF-2402) (V2LY-0925-LY1784)

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Basic Information

Host Animal
Rat
Clone
CBXF-2402
Application
WB
Immunogen
Recombinant mouse FGF R5/FGFRL1 (Ala21-Pro374).
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
ApplicationNote
WB1 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS & Trehalose
Preservative
None
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Fibroblast Growth Factor Receptor Like 1
Entrez Gene ID
UniProt ID
Function
Has a negative effect on cell proliferation.
Biological Process
Cell-cell adhesion via plasma-membrane adhesion molecules Source: UniProtKB
Diaphragm development Source: Ensembl
Heart valve morphogenesis Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Skeletal system development Source: Ensembl
Ventricular septum morphogenesis Source: Ensembl
Cellular Location
Membrane. Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.
Topology
Extracellular: 25-378
Helical: 379-399
Cytoplasmic: 400-504

Guan, L., Dong, Y., Chen, S., Wang, C., Feng, L., Xie, Y., & Tang, X. (2022). Overexpression of fibroblast growth factor receptor like 1 (FGFRL1) inhibits proliferation and migration of HCT116 human colon cancer cells, and promotes their apoptosis. Xi bao yu fen zi Mian yi xue za zhi= Chinese Journal of Cellular and Molecular Immunology, 38(3), 251-256.

Cho, H. W., Jin, H. S., & Eom, Y. B. (2022). FGFRL1 and FGF genes are associated with height, hypertension, and osteoporosis. Plos one, 17(8), e0273237.

Gofin, Y., Mackay, L. P., Machol, K., Keswani, S., Potocki, L., Di Gregorio, E., ... & Scott, D. A. (2021). Evidence that FGFRL1 contributes to congenital diaphragmatic hernia development in humans. American Journal of Medical Genetics Part A, 185(3), 836-840.

Zhuang, L., Vogel, M., Villiger, P. M., & Trueb, B. (2020). Dissecting the interaction of FGF8 with receptor FGFRL1. Biomolecules, 10(10), 1399.

Chen, R., Li, D., Zheng, M., Chen, B., Wei, T., Wang, Y., ... & Fang, S. (2020). FGFRL1 affects chemoresistance of small‐cell lung cancer by modulating the PI3K/Akt pathway via ENO1. Journal of cellular and molecular medicine, 24(3), 2123-2134.

Fan, Y., Li, H., Yu, Z., Dong, W., Cui, X., Ma, J., & Li, S. (2020). Long non-coding RNA FGD5-AS1 promotes non-small cell lung cancer cell proliferation through sponging hsa-miR-107 to up-regulate FGFRL1. Bioscience reports, 40(1).

Wang, L., He, J., Hu, H., Tu, L., Sun, Z., Liu, Y., & Luo, F. (2020). Lung CSC‐derived exosomal miR‐210‐3p contributes to a pro‐metastatic phenotype in lung cancer by targeting FGFRL1. Journal of Cellular and Molecular Medicine, 24(11), 6324-6339.

Gerber, S. D., Beauchamp, P., Zhuang, L., Villiger, P. M., & Trueb, B. (2020). Functional domains of the FgfrL1 receptor. Developmental biology, 461(1), 43-54.

Liu, X., Zhang, C., Wang, C., Sun, J., Wang, D., Zhao, Y., & Xu, X. (2018). miR‑210 promotes human osteosarcoma cell migration and invasion by targeting FGFRL1. Oncology Letters, 16(2), 2229-2236.

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For research use only. Not intended for any clinical use.

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