Mouse Recombinant FGFRL1 protein, His Tag (V2LY-0526-LY8323)

Name: Mouse Recombinant FGFRL1 protein, His Tag
SKU: V2LY-0526-LY8323
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant FGFRL1 protein, His Tag consist of Amino Acid: 1-374 and predicts a molecular mass of 40.4 kDa.

Molecule Mass

40.4 kDa

Sequence

Amino Acid: 1-374

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS, Tween80

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Fibroblast Growth Factor Receptor Like 1

Function

Has a negative effect on cell proliferation.

Biological Process

Cell-cell adhesion via plasma-membrane adhesion molecules Source: UniProtKB
Diaphragm development Source: Ensembl
Heart valve morphogenesis Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Skeletal system development Source: Ensembl
Ventricular septum morphogenesis Source: Ensembl

Cellular Location

Membrane. Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.

Topology

Extracellular: 25-378
Helical: 379-399
Cytoplasmic: 400-504

Guan, L., Dong, Y., Chen, S., Wang, C., Feng, L., Xie, Y., & Tang, X. (2022). Overexpression of fibroblast growth factor receptor like 1 (FGFRL1) inhibits proliferation and migration of HCT116 human colon cancer cells, and promotes their apoptosis. Xi bao yu fen zi Mian yi xue za zhi= Chinese Journal of Cellular and Molecular Immunology, 38(3), 251-256.

Cho, H. W., Jin, H. S., & Eom, Y. B. (2022). FGFRL1 and FGF genes are associated with height, hypertension, and osteoporosis. Plos one, 17(8), e0273237.

Gofin, Y., Mackay, L. P., Machol, K., Keswani, S., Potocki, L., Di Gregorio, E., ... & Scott, D. A. (2021). Evidence that FGFRL1 contributes to congenital diaphragmatic hernia development in humans. American Journal of Medical Genetics Part A, 185(3), 836-840.

Zhuang, L., Vogel, M., Villiger, P. M., & Trueb, B. (2020). Dissecting the interaction of FGF8 with receptor FGFRL1. Biomolecules, 10(10), 1399.

Chen, R., Li, D., Zheng, M., Chen, B., Wei, T., Wang, Y., ... & Fang, S. (2020). FGFRL1 affects chemoresistance of small‐cell lung cancer by modulating the PI3K/Akt pathway via ENO1. Journal of cellular and molecular medicine, 24(3), 2123-2134.

Fan, Y., Li, H., Yu, Z., Dong, W., Cui, X., Ma, J., & Li, S. (2020). Long non-coding RNA FGD5-AS1 promotes non-small cell lung cancer cell proliferation through sponging hsa-miR-107 to up-regulate FGFRL1. Bioscience reports, 40(1).

Wang, L., He, J., Hu, H., Tu, L., Sun, Z., Liu, Y., & Luo, F. (2020). Lung CSC‐derived exosomal miR‐210‐3p contributes to a pro‐metastatic phenotype in lung cancer by targeting FGFRL1. Journal of Cellular and Molecular Medicine, 24(11), 6324-6339.

Gerber, S. D., Beauchamp, P., Zhuang, L., Villiger, P. M., & Trueb, B. (2020). Functional domains of the FgfrL1 receptor. Developmental biology, 461(1), 43-54.

Liu, X., Zhang, C., Wang, C., Sun, J., Wang, D., Zhao, Y., & Xu, X. (2018). miR‑210 promotes human osteosarcoma cell migration and invasion by targeting FGFRL1. Oncology Letters, 16(2), 2229-2236.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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