Mouse Anti-FLI1 Recombinant Antibody (CBT2007) (V2LY-0625-LY1478)

Name: Mouse Anti-FLI1 Recombinant Antibody (CBT2007)
SKU: V2LY-0625-LY1478
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBT2007

Antibody Isotype

IgG2b

Application

IHC, FC

Basic Information

Immunogen

Purified recombinant fragment of human FLI1 (AA: 303-452) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Friend leukemia integration 1 transcription factor

Entrez Gene ID

2313

UniProt ID

Q01543

Function

Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014).

Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.

Biological Process

Animal organ morphogenesis Source: ProtInc
Blood circulation Source: Ensembl
Cell differentiation Source: GO_Central
Hemostasis Source: ProtInc
Megakaryocyte development Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Involvement in disease

Ewing sarcoma (ES):
A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Bleeding disorder, platelet-type, 21 (BDPLT21):
A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. BDPLT21 patients may have mild to moderate thrombocytopenia.

More Infomation

References

Chen, B., Sheng, D., Wang, C., Liu, W., Hu, A., Xiao, X., ... & Ben-David, Y. (2022). FLI1 regulates inflammation-associated genes to accelerate leukemogenesis. Cellular Signalling, 92, 110269.

Li, L. L., Yu, J., Cheng, S., Peng, Z. L., Ben-David, Y., & Luo, H. (2022). Transcription factor Fli-1 as a new target for antitumor drug development. International Journal of Biological Macromolecules.

Ben-David, Y., Gajendran, B., Sample, K. M., & Zacksenhaus, E. (2022). Current insights into the role of Fli-1 in hematopoiesis and malignant transformation. Cellular and Molecular Life Sciences, 79(3), 163.

Sato, S., Zhang, X. K., Temmoku, J., Fujita, Y., Matsuoka, N., Yashiro-Furuya, M., ... & Migita, K. (2020). Ets family transcription factor Fli-1 promotes leukocyte recruitment and production of IL-17A in the MRL/Lpr mouse model of lupus nephritis. Cells, 9(3), 714.

Ma, Y., Xu, B., Yu, J., Huang, L., Zeng, X., Shen, X., ... & Luo, H. (2020). Fli-1 activation through targeted promoter activity regulation using a novel 3’, 5’-diprenylated chalcone inhibits growth and metastasis of prostate cancer cells. International Journal of Molecular Sciences, 21(6), 2216.

Chen, N., Zhao, G., Yan, X., Lv, Z., Yin, H., Zhang, S., ... & Cui, J. (2018). A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1. Genome biology, 19(1), 1-14.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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