FLI1
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Full Name
Friend leukemia integration 1 transcription factor
Function
Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014).
Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
Biological Process
Animal organ morphogenesis Source: ProtInc
Blood circulation Source: Ensembl
Cell differentiation Source: GO_Central
Hemostasis Source: ProtInc
Megakaryocyte development Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Blood circulation Source: Ensembl
Cell differentiation Source: GO_Central
Hemostasis Source: ProtInc
Megakaryocyte development Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Ewing sarcoma (ES):
A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Bleeding disorder, platelet-type, 21 (BDPLT21):
A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. BDPLT21 patients may have mild to moderate thrombocytopenia.
A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Bleeding disorder, platelet-type, 21 (BDPLT21):
A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. BDPLT21 patients may have mild to moderate thrombocytopenia.
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Anti-FLI1 antibodies
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CompareTarget: FLI1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0733
Application*: E, WB
Target: FLI1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: B2
Application*: WB
Target: FLI1
Host: Mouse
Specificity: Human
Clone: IHC576
Application*: IH
Target: FLI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Zebrafish
Clone: D7N5M
Application*: WB, IP
Target: FLI1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1H4
Application*: WB, E
Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 1F6
Application*: WB, E
Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E6
Application*: WB, E
Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: CBXF-3070
Application*: E, WB
Target: FLI1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-3069
Application*: E, IP, WB
Target: FLI1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-3065
Application*: E, IF, WB
Target: FLI1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-1754
Application*: WB, IP, IF, E
Target: FLI1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1753
Application*: WB, IP, IF, E
Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: CBXF-0735
Application*: IF, E, WB
Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-2335
Application*: IP
Target: FLI1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: G146-22
Application*: C, P
Target: FLI1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: FLVI1-1
Application*: F, IF, WB
Target: FLI1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Mouse
Clone: CBXF-2242
Application*: CI, IF, WB
Target: FLI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Zebrafish
Clone: CBXF-0734
Application*: WB, IP
Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-3716
Application*: IF, WB
Target: FLI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBXF-1202
Application*: WB, P
Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4H6
Application*: IP, M
Target: FLI1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT2007
Application*: IH, F
Target: FLI1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT2670
Application*: IH, F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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