FLI1

This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Full Name
Friend leukemia integration 1 transcription factor
Function
Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014).

Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
Biological Process
Animal organ morphogenesis Source: ProtInc
Blood circulation Source: Ensembl
Cell differentiation Source: GO_Central
Hemostasis Source: ProtInc
Megakaryocyte development Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Ewing sarcoma (ES):
A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Bleeding disorder, platelet-type, 21 (BDPLT21):
A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. BDPLT21 patients may have mild to moderate thrombocytopenia.
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Anti-FLI1 antibodies

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Mouse Anti-FLI1 Recombinant Antibody (CBXF-0733) (CBMAB-F0435-CQ)

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Target: FLI1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-0733
Application*: WB, IP, E, IF
Datasheet SDS

Mouse Anti-FLI1 Recombinant Antibody (2E6) (CBMAB-A3003-LY)

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Target: FLI1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2E6
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-FLI1 Recombinant Antibody (CBXF-3070) (CBMAB-F3767-CQ)

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Target: FLI1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXF-3070
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-FLI1 Recombinant Antibody (CBXF-3069) (CBMAB-F3766-CQ)

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Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-3069
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-FLI1 Recombinant Antibody (CBXF-3065) (CBMAB-F3762-CQ)

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Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: CBXF-3065
Application*: E, WB
Datasheet SDS

Mouse Anti-FLI1 Recombinant Antibody (CBXF-1754) (CBMAB-F3289-CQ)

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Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: CBXF-1754
Application*: E, WB
Datasheet SDS

Mouse Anti-FLI1 Recombinant Antibody (CBXF-1753) (CBMAB-F3288-CQ)

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Target: FLI1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-1753
Application*: E
Datasheet SDS

Mouse Anti-FLI1 Recombinant Antibody (CBXF-0735) (CBMAB-F3187-CQ)

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Target: FLI1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0735
Application*: WB, IP, E, IF
Datasheet SDS

Mouse Anti-FLI1 Recombinant Antibody (CBXF-2335) (CBMAB-F2814-CQ)

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Target: FLI1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBXF-2335
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-FLI1 Recombinant Antibody (22) (CBMAB-F2564-CQ)

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Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 22
Application*: E, WB
Datasheet SDS

Rabbit Anti-FLI1 Recombinant Antibody (CBXF-0734) (CBMAB-F1394-CQ)

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Target: FLI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0734
Application*: WB, IP
Datasheet SDS

Rabbit Anti-FLI1 Recombinant Antibody (CBXF-1202) (CBMAB-F0196-CQ)

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Target: FLI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1202
Application*: IH
Datasheet SDS

Rabbit Anti-FLI1 Recombinant Antibody (
4E5) (V2LY-0725-LY1042)

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Target: FLI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 4E5
Application*: E, WB
Datasheet SDS

Mouse Anti-FLI1 Recombinant Antibody (CBT2007) (V2LY-0625-LY1478)

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Target: FLI1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT2007
Application*: IH, F
Datasheet SDS

Mouse Anti-FLI1 Recombinant Antibody (CBT2670) (V2LY-0625-LY1476)

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Target: FLI1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT2670
Application*: IH, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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