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FLI1

This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Full Name
Friend leukemia integration 1 transcription factor
Function
Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014).

Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
Biological Process
Animal organ morphogenesis Source: ProtInc
Blood circulation Source: Ensembl
Cell differentiation Source: GO_Central
Hemostasis Source: ProtInc
Megakaryocyte development Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Ewing sarcoma (ES):
A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Bleeding disorder, platelet-type, 21 (BDPLT21):
A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. BDPLT21 patients may have mild to moderate thrombocytopenia.

Anti-FLI1 antibodies

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Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E6
Application*: WB, E
Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 1F6
Application*: WB, E
Target: FLI1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1H4
Application*: WB, E
Target: FLI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Zebrafish
Clone: D7N5M
Application*: WB, IP
Target: FLI1
Host: Mouse
Specificity: Human
Clone: IHC576
Application*: IH
Target: FLI1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: B2
Application*: WB
Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4H6
Application*: IP, M
Target: FLI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBXF-1202
Application*: WB, P
Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0733
Application*: E, WB
Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-3716
Application*: IF, WB
Target: FLI1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Zebrafish
Clone: CBXF-0734
Application*: WB, IP
Target: FLI1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Mouse
Clone: CBXF-2242
Application*: CI, IF, WB
Target: FLI1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: FLVI1-1
Application*: F, IF, WB
Target: FLI1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: G146-22
Application*: C, P
Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-2335
Application*: IP
Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: CBXF-0735
Application*: IF, E, WB
Target: FLI1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1753
Application*: WB, IP, IF, E
Target: FLI1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-1754
Application*: WB, IP, IF, E
Target: FLI1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-3065
Application*: E, IF, WB
Target: FLI1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-3069
Application*: E, IP, WB
Target: FLI1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: CBXF-3070
Application*: E, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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