Rabbit Anti-FLI1 Recombinant Antibody (CBXF-1202) (CBMAB-F0196-CQ)

Name: Rabbit Anti-FLI1 Recombinant Antibody (CBXF-1202)
SKU: CBMAB-F0196-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXF-1202

Application

WB, IHC-P

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Friend leukemia integration 1 transcription factor

Introduction

This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

Human	2313
Mouse	14247

UniProt ID

Human	Q01543
Mouse	P26323

Alternative Names

Fli-1 Proto-Oncogene, ETS Transcription Factor; Friend Leukemia Virus Integration 1; Transcription Factor ERGB; Friend Leukemia Integration 1 Transcription Factor; Ewing Sarcoma Breakpoint Region 2; Proto-Oncogene Fli-1; BDPLT21; EWSR2; SIC-1;

Function

Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014).

Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.

Biological Process

Animal organ morphogenesis Source: ProtInc
Blood circulation Source: Ensembl
Cell differentiation Source: GO_Central
Hemostasis Source: ProtInc
Megakaryocyte development Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Involvement in disease

Ewing sarcoma (ES):
A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Bleeding disorder, platelet-type, 21 (BDPLT21):
A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. BDPLT21 patients may have mild to moderate thrombocytopenia.

Chen, B., Sheng, D., Wang, C., Liu, W., Hu, A., Xiao, X., ... & Ben-David, Y. (2022). FLI1 regulates inflammation-associated genes to accelerate leukemogenesis. Cellular Signalling, 92, 110269.

Li, L. L., Yu, J., Cheng, S., Peng, Z. L., Ben-David, Y., & Luo, H. (2022). Transcription factor Fli-1 as a new target for antitumor drug development. International Journal of Biological Macromolecules.

Ben-David, Y., Gajendran, B., Sample, K. M., & Zacksenhaus, E. (2022). Current insights into the role of Fli-1 in hematopoiesis and malignant transformation. Cellular and Molecular Life Sciences, 79(3), 163.

Sato, S., Zhang, X. K., Temmoku, J., Fujita, Y., Matsuoka, N., Yashiro-Furuya, M., ... & Migita, K. (2020). Ets family transcription factor Fli-1 promotes leukocyte recruitment and production of IL-17A in the MRL/Lpr mouse model of lupus nephritis. Cells, 9(3), 714.

Ma, Y., Xu, B., Yu, J., Huang, L., Zeng, X., Shen, X., ... & Luo, H. (2020). Fli-1 activation through targeted promoter activity regulation using a novel 3’, 5’-diprenylated chalcone inhibits growth and metastasis of prostate cancer cells. International Journal of Molecular Sciences, 21(6), 2216.

Chen, N., Zhao, G., Yan, X., Lv, Z., Yin, H., Zhang, S., ... & Cui, J. (2018). A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1. Genome biology, 19(1), 1-14.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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