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Mouse Anti-FLRT2 Recombinant Antibody (CBXF-3341) (CBMAB-F0662-CQ)

This product is a mouse antibody that recognizes FLRT2. The antibody CBXF-3341 can be used for immunoassay techniques such as: WB.
See all FLRT2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-3341
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
NS0-derived recombinant human FLRT2 Cys36-Ser539
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 5% trehalose
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fibronectin Leucine Rich Transmembrane Protein 2
Introduction
This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
23768
UniProt ID
O43155
Alternative Names
Fibronectin Leucine Rich Transmembrane Protein 2; Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 2; KIAA0405;
Function
Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.
Biological Process
Axon guidance Source: Ensembl
Basement membrane organization Source: UniProtKB
Cell adhesion involved in heart morphogenesis Source: UniProtKB
Fibroblast growth factor receptor signaling pathway Source: UniProtKB
Heart morphogenesis Source: UniProtKB
Positive regulation of synapse assembly Source: Ensembl
Regulation of neuron migration Source: Ensembl
Cellular Location
Endoplasmic reticulum membrane; Microsome membrane; Cell membrane; Extracellular matrix; Secreted; Focal adhesion; Synaptosome. Proteolytic cleavage gives rise to a shedded ectodomain.
Topology
Extracellular: 36-541
Helical: 542-562
Cytoplasmic: 563-660
PTM
N-glycosylated.
Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease.

Ando, T., Tai-Nagara, I., Sugiura, Y., Kusumoto, D., Okabayashi, K., Kido, Y., ... & Kubota, Y. (2022). Tumor-specific interendothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness. The Journal of clinical investigation, 132(6).

Prigge, C. L., Sharma, A., Dembla, M., El-Quessny, M., Kozlowski, C., Paisley, C. E., ... & Kay, J. N. (2022). Rejection of inappropriate synaptic partners mediated by transcellular FLRT2-UNC5 signaling. bioRxiv, 2022-08.

Jackson, V., Hermann, J., Tynan, C. J., Rolfe, D. J., Corey, R. A., Duncan, A. L., ... & Chavent, M. (2022). The guidance and adhesion protein FLRT2 dimerizes in cis via dual Small-X3-Small transmembrane motifs. Structure, 30(9), 1354-1365.

Fleitas, C., Marfull-Oromí, P., Chauhan, D., Del Toro, D., Peguera, B., Zammou, B., ... & Egea, J. (2021). FLRT2 and FLRT3 cooperate in maintaining the tangential migratory streams of cortical interneurons during development. Journal of Neuroscience, 41(35), 7350-7362.

Li, J., Shinoda, Y., Ogawa, S., Ikegaya, S., Li, S., Matsuyama, Y., ... & Yamagishi, S. (2021). Expression of FLRT2 in Postnatal Central Nervous System Development and After Spinal Cord Injury. Frontiers in Molecular Neuroscience, 241.

Fleitas Pérez, C., Marfull Oromí, P., Chauhan, D., Toro, D. D., Peguera, B., Zammou, B., ... & Egea Navarro, J. (2021). FLRT2 and FLRT3 Cooperate in Maintaining the Tangential Migratory Streams of Cortical Interneurons during Development. Journal of Neuroscience, 2021, vol. 41, núm. 35, 7350-7362.

Guo, X., Song, C., Fang, L., Li, M., Yue, L., & Sun, Q. (2020). FLRT2 functions as Tumor Suppressor gene inactivated by promoter methylation in Colorectal Cancer. Journal of Cancer, 11(24), 7329.

Shirakawa, J., Takegahara, N., Kim, H., Lee, S. H., Sato, K., Yamagishi, S., & Choi, Y. (2019). Flrt2 is involved in fine-tuning of osteoclast multinucleation. BMB reports, 52(8), 514.

Cicvaric, A., Yang, J., Bulat, T., Zambon, A., Dominguez-Rodriguez, M., Kühn, R., ... & Monje, F. J. (2018). Enhanced synaptic plasticity and spatial memory in female but not male FLRT2-haplodeficient mice. Scientific Reports, 8(1), 1-13.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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