Rabbit Anti-FOXP2 Recombinant Antibody (D55H9) (CBMAB-F1953-CQ)

Name: Rabbit Anti-FOXP2 Recombinant Antibody (D55H9)
SKU: CBMAB-F1953-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

D55H9

Application

IP, WB

Immunogen

Synthetic peptide corresponding to residues surrounding Leu623 of human FoxP2 protein

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.01 M HEPES, 0.15M NaCl, 100ug/ml BSA, 50% glycerol, pH 7.5

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Forkhead Box P2

Introduction

This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.

Entrez Gene ID

93986

UniProt ID

O15409

Alternative Names

Forkhead Box P2; CAG Repeat Protein 44; Trinucleotide Repeat-Containing Gene 10 Protein; Forkhead/Winged-Helix Transcription Factor; Trinucleotide Repeat Containing 10; TNRC10;

Function

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.

Biological Process

Caudate nucleus development Source: UniProtKB
Cerebral cortex development Source: BHF-UCL
Innate vocalization behavior Source: Ensembl
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Putamen development Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to testosterone Source: Ensembl

Cellular Location

Nucleus

Involvement in disease

Speech-language disorder 1 (SPCH1):
A disorder characterized by severe orofacial dyspraxia resulting in largely incomprehensible speech. Affected individuals have severe impairment in the selection and sequencing of fine orofacial movements which are necessary for articulation, and deficits in several facets of grammatical skills and language processing, such as the ability to break up words into their constituent phonemes.

Den Hoed, J., Devaraju, K., & Fisher, S. E. (2021). Molecular networks of the FOXP2 transcription factor in the brain. EMBO reports, 22(8), e52803.

Medvedeva, V. P., Rieger, M. A., Vieth, B., Mombereau, C., Ziegenhain, C., Ghosh, T., ... & Groszer, M. (2019). Altered social behavior in mice carrying a cortical Foxp2 deletion. Human molecular genetics, 28(5), 701-717.

Häußermann, K., Young, G., Kukura, P., & Dietz, H. (2019). Dissecting FOXP2 oligomerization and DNA binding. Angewandte Chemie, 131(23), 7744-7749.

French, C. A., Vinueza Veloz, M. F., Zhou, K., Peter, S., Fisher, S. E., Costa, R. M., & De Zeeuw, C. I. (2019). Differential effects of Foxp2 disruption in distinct motor circuits. Molecular psychiatry, 24(3), 447-462.

Fisher, S. E. (2019). Human genetics: the evolving story of FOXP2. Current Biology, 29(2), R65-R67.

Herrero, M. J., & Gitton, Y. (2018). The untold stories of the speech gene, the FOXP2 cancer gene. Genes & cancer, 9(1-2), 11.

Atkinson, E. G., Audesse, A. J., Palacios, J. A., Bobo, D. M., Webb, A. E., Ramachandran, S., & Henn, B. M. (2018). No evidence for recent selection at FOXP2 among diverse human populations. Cell, 174(6), 1424-1435.

Kuhlwilm, M. (2018). The evolution of FOXP2 in the light of admixture. Current opinion in behavioral sciences, 21, 120-126.

Becker, M., Devanna, P., Fisher, S. E., & Vernes, S. C. (2018). Mapping of human FOXP2 enhancers reveals complex regulation. Frontiers in molecular neuroscience, 11, 47.

Xu, S., Liu, P., Chen, Y., Chen, Y., Zhang, W., Zhao, H., ... & Guo, X. (2018). Foxp2 regulates anatomical features that may be relevant for vocal behaviors and bipedal locomotion. Proceedings of the National Academy of Sciences, 115(35), 8799-8804.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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