FOXP2

This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
Full Name
Forkhead Box P2
Function
Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.
Biological Process
Caudate nucleus development Source: UniProtKB
Cerebral cortex development Source: BHF-UCL
Innate vocalization behavior Source: Ensembl
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Putamen development Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to testosterone Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
Speech-language disorder 1 (SPCH1):
A disorder characterized by severe orofacial dyspraxia resulting in largely incomprehensible speech. Affected individuals have severe impairment in the selection and sequencing of fine orofacial movements which are necessary for articulation, and deficits in several facets of grammatical skills and language processing, such as the ability to break up words into their constituent phonemes.
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Anti-FOXP2 antibodies

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Mouse Anti-FOXP2 Recombinant Antibody (CBT4750) (V2LY-0625-LY465)

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Target: FOXP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4750
Application*: WB, F
Datasheet SDS

Mouse Anti-FOXP2 Recombinant Antibody (CBT568) (V2LY-0625-LY3420)

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Target: FOXP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT568
Application*: WB, E
Datasheet SDS

Mouse Anti-FOXP2 Recombinant Antibody (CBT569) (V2LY-0625-LY3419)

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Target: FOXP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT569
Application*: WB, E
Datasheet SDS

Mouse Anti-FOXP2 Recombinant Antibody (CBT4745) (V2LY-0625-LY2661)

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Target: FOXP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4745
Application*: WB
Datasheet SDS

Mouse Anti-FOXP2 Recombinant Antibody (CBT3774) (V2LY-0625-LY2660)

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Target: FOXP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3774
Application*: WB
Datasheet SDS

Mouse Anti-FOXP2 Recombinant Antibody (1F8) (CBMAB-A3156-LY)

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Target: FOXP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1F8
Application*: WB, E
Datasheet SDS

Rabbit Anti-FOXP2 Recombinant Antibody (CBXF-1510) (CBMAB-F4135-CQ)

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Target: FOXP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1510
Application*: IP, WB
Datasheet SDS

Mouse Anti-FOXP2 Recombinant Antibody (CBXF-3180) (CBMAB-F3876-CQ)

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Target: FOXP2
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBXF-3180
Application*: E, WB
Datasheet SDS

Mouse Anti-FOXP2 Recombinant Antibody (CBXF-3179) (CBMAB-F3875-CQ)

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Target: FOXP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-3179
Application*: E, WB
Datasheet SDS

Mouse Anti-FOXP2 Recombinant Antibody (CBXF-0877) (CBMAB-F3211-CQ)

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Target: FOXP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-0877
Application*: IF, SE, E, WB
Datasheet SDS

Mouse Anti-FOXP2 (AA 657-684) Recombinant Antibody (CBXF-0880) (CBMAB-F2469-CQ)

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Target: FOXP2
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBXF-0880
Application*: WB
Datasheet SDS

Mouse Anti-FOXP2 (AA 616-716) Recombinant Antibody (CBXF-0878) (CBMAB-F2468-CQ)

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Target: FOXP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-0878
Application*: E, WB
Datasheet SDS

Mouse Anti-FOXP2 Recombinant Antibody (5C11A8) (CBMAB-F1954-CQ)

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Target: FOXP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5C11A8
Application*: WB
Datasheet SDS

Rabbit Anti-FOXP2 Recombinant Antibody (D55H9) (CBMAB-F1953-CQ)

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Target: FOXP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D55H9
Application*: IP, WB
Datasheet SDS

Mouse Anti-FOXP2 Recombinant Antibody (CBXF-1953) (CBMAB-F1801-CQ)

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Target: FOXP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1953
Application*: WB, P
Datasheet SDS

Mouse Anti-FOXP2 Recombinant Antibody (CBXF-2030) (CBMAB-F1157-CQ)

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Target: FOXP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2030
Application*: E, WB, F
Datasheet SDS

Mouse Anti-FOXP2 Recombinant Antibody (FOXP2-73A/8) (CBMAB-F1093-CQ)

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Target: FOXP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: FOXP2-73A/8
Application*: IS
Datasheet SDS

Mouse Anti-FOXP2 Recombinant Antibody (CBXF-0879) (CBMAB-F0468-CQ)

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Target: FOXP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-0879
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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