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Mouse Anti-FOXP2 (AA 657-684) Recombinant Antibody (CBXF-0880) (CBMAB-F2469-CQ)

This product is a mouse antibody that recognizes FOXP2 (AA 657-684). The antibody CBXF-0880 can be used for immunoassay techniques such as: WB.
See all FOXP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0880
Antibody Isotype
IgM
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascitic fluid
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 657-684

Target

Full Name
Forkhead Box P2
Introduction
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
Entrez Gene ID
93986
UniProt ID
O15409
Alternative Names
Forkhead Box P2; CAG Repeat Protein 44; Trinucleotide Repeat-Containing Gene 10 Protein; Forkhead/Winged-Helix Transcription Factor; Trinucleotide Repeat Containing 10; TNRC10;
Function
Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.
Biological Process
Caudate nucleus development Source: UniProtKB
Cerebral cortex development Source: BHF-UCL
Innate vocalization behavior Source: Ensembl
Negative regulation of transcription, DNA-templated Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Putamen development Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to testosterone Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
Speech-language disorder 1 (SPCH1):
A disorder characterized by severe orofacial dyspraxia resulting in largely incomprehensible speech. Affected individuals have severe impairment in the selection and sequencing of fine orofacial movements which are necessary for articulation, and deficits in several facets of grammatical skills and language processing, such as the ability to break up words into their constituent phonemes.

Den Hoed, J., Devaraju, K., & Fisher, S. E. (2021). Molecular networks of the FOXP2 transcription factor in the brain. EMBO reports, 22(8), e52803.

Medvedeva, V. P., Rieger, M. A., Vieth, B., Mombereau, C., Ziegenhain, C., Ghosh, T., ... & Groszer, M. (2019). Altered social behavior in mice carrying a cortical Foxp2 deletion. Human molecular genetics, 28(5), 701-717.

Häußermann, K., Young, G., Kukura, P., & Dietz, H. (2019). Dissecting FOXP2 oligomerization and DNA binding. Angewandte Chemie, 131(23), 7744-7749.

French, C. A., Vinueza Veloz, M. F., Zhou, K., Peter, S., Fisher, S. E., Costa, R. M., & De Zeeuw, C. I. (2019). Differential effects of Foxp2 disruption in distinct motor circuits. Molecular psychiatry, 24(3), 447-462.

Fisher, S. E. (2019). Human genetics: the evolving story of FOXP2. Current Biology, 29(2), R65-R67.

Herrero, M. J., & Gitton, Y. (2018). The untold stories of the speech gene, the FOXP2 cancer gene. Genes & cancer, 9(1-2), 11.

Atkinson, E. G., Audesse, A. J., Palacios, J. A., Bobo, D. M., Webb, A. E., Ramachandran, S., & Henn, B. M. (2018). No evidence for recent selection at FOXP2 among diverse human populations. Cell, 174(6), 1424-1435.

Kuhlwilm, M. (2018). The evolution of FOXP2 in the light of admixture. Current opinion in behavioral sciences, 21, 120-126.

Becker, M., Devanna, P., Fisher, S. E., & Vernes, S. C. (2018). Mapping of human FOXP2 enhancers reveals complex regulation. Frontiers in molecular neuroscience, 11, 47.

Xu, S., Liu, P., Chen, Y., Chen, Y., Zhang, W., Zhao, H., ... & Guo, X. (2018). Foxp2 regulates anatomical features that may be relevant for vocal behaviors and bipedal locomotion. Proceedings of the National Academy of Sciences, 115(35), 8799-8804.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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