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Mouse Anti-FOXP4 Recombinant Antibody (3B12) (CBMAB-A3157-LY)

The product is antibody recognizes FOXP4. The antibody 3B12 immunoassay techniques such as: WB, ELISA.
See all FOXP4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3B12
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
FOXP4 (NP_001012426.1, 586 a.a. ~ 679 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
FOXP4
Introduction
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq]
Entrez Gene ID
116113
UniProt ID
Q8IVH2
Alternative Names
FLJ40908; FLJ44184; hFKHLA
Function
Transcriptional repressor that represses lung-specific expression.
Biological Process
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Xue, P., Huang, S., Han, X., Zhang, C., Yang, L., Xiao, W., ... & Zhou, Y. (2022). Exosomal miR-101-3p and miR-423-5p inhibit medulloblastoma tumorigenesis through targeting FOXP4 and EZH2. Cell Death & Differentiation, 29(1), 82-95.

Yang, L., Liu, Z., Ma, J., Wang, H., Gao, D., Zhang, C., & Ma, Q. (2021). CircRPPH1 serves as a sponge for miR-296-5p to enhance progression of breast cancer by regulating FOXP4 expression. American Journal of Translational Research, 13(7), 7556.

Zhao, J., Yang, T., & Li, L. (2020). LncRNA FOXP4-AS1 is involved in cervical cancer progression via regulating miR-136-5p/CBX4 axis. OncoTargets and therapy, 13, 2347.

Liang, H., Huang, H., Li, Y., Lu, Y., & Ye, T. (2020). CircRNA_0058063 functions as a ceRNA in bladder cancer progression via targeting miR-486-3p/FOXP4 axis. Bioscience Reports, 40(3).

Wang, X., Liu, L., Zhao, W., Li, Q., Wang, G., & Li, H. (2020). LncRNA SNHG16 promotes the progression of laryngeal squamous cell carcinoma by mediating miR-877-5p/FOXP4 axis. OncoTargets and therapy, 13, 4569.

Li, Y., Li, T., Yang, Y., Kang, W., Dong, S., & Cheng, S. (2020). YY1‐induced upregulation of FOXP4‐AS1 and FOXP4 promote the proliferation of esophageal squamous cell carcinoma cells. Cell biology international, 44(7), 1447-1457.

Huang, C., Deng, H., Wang, Y., Jiang, H., Xu, R., Zhu, X., ... & Zhao, X. (2019). Circular RNA circABCC4 as the ceRNA of miR‐1182 facilitates prostate cancer progression by promoting FOXP4 expression. Journal of cellular and molecular medicine, 23(9), 6112-6119.

Wu, X., Xiao, Y., Zhou, Y., Zhou, Z., & Yan, W. (2019). LncRNA FOXP4-AS1 is activated by PAX5 and promotes the growth of prostate cancer by sequestering miR-3184-5p to upregulate FOXP4. Cell death & disease, 10(7), 472.

Zhang, G., & Zhang, G. (2019). Upregulation of FoxP4 in HCC promotes migration and invasion through regulation of EMT. Oncology letters, 17(4), 3944-3951.

Xiong, Y., Zhang, J., & Song, C. (2019). CircRNA ZNF609 functions as a competitive endogenous RNA to regulate FOXP4 expression by sponging miR‐138‐5p in renal carcinoma. Journal of cellular physiology, 234(7), 10646-10654.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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