Mouse Anti-FOXS1 Recombinant Antibody (CBXF-1797) (CBMAB-F3332-CQ)

This product is a mouse antibody that recognizes FOXS1. The antibody CBXF-1797 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all FOXS1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Mouse, Rat

Clone

CBXF-1797

Antibody Isotype

IgG

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Forkhead Box S1

Introduction

The forkhead family of transcription factors belongs to the winged helix class of DNA-binding proteins. The protein encoded by this intronless gene contains a forkhead domain and is found predominantly in aorta and kidney. The function of the encoded protein is unknown.

Entrez Gene ID

Rat	311547
Mouse	14239

UniProt ID

Rat	Q5HZE9
Mouse	Q61574

Alternative Names

Forkhead Box S1; Forkhead-Related Transcription Factor 10; Forkhead-Like 18 Protein; FREAC-10; FREAC10; FKHL18;

Function

Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity).

Biological Process

Anatomical structure morphogenesis Source: GO_Central
Blood vessel development Source: UniProtKB
Cell differentiation Source: GO_Central
Negative regulation of DNA-binding transcription factor activity Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Neuromuscular process controlling balance Source: Ensembl
Positive regulation of multicellular organism growth Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

References

Bévant, K., Desoteux, M., Angenard, G., Pineau, R., Caruso, S., Louis, C., ... & Coulouarn, C. (2022). TGFβ‐induced FOXS1 controls epithelial–mesenchymal transition and predicts a poor prognosis in liver cancer. Hepatology Communications, 6(5), 1157-1171.

Liu, Y., Tu, M., & Wang, L. (2022). Pan-cancer analysis predicts FOXS1 as a key target in prognosis and tumor immunotherapy. International Journal of General Medicine, 2171-2185.

Xue, B. Z., Xiang, W., Zhang, Q., Wang, H. F., Zhou, Y. J., Tian, H., ... & Fu, P. (2021). CD90 low glioma-associated mesenchymal stromal/stem cells promote temozolomide resistance by activating FOXS1-mediated epithelial-mesenchymal transition in glioma cells. Stem Cell Research & Therapy, 12, 1-11.

Wang, S., Ran, L., Zhang, W., Leng, X., Wang, K., Liu, G., ... & Song, F. (2019). FOXS1 is regulated by GLI1 and miR-125a-5p and promotes cell proliferation and EMT in gastric cancer. Scientific Reports, 9(1), 5281.

Lu, Q., Ma, X., Li, Y., Song, W., Zhang, L., Shu, Y., & Wan, B. (2019). Overexpression of FOXS1 in gastric cancer cell lines inhibits proliferation, metastasis, and epithelial‐mesenchymal transition of tumor through downregulating wnt/β‐catenin pathway. Journal of Cellular Biochemistry, 120(3), 2897-2907.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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