Mouse Anti-FRA10AC1 Recombinant Antibody (CBLC220-LY) (CBMAB-C11602-LY)

Name: Mouse Anti-FRA10AC1 Recombinant Antibody (CBLC220-LY)
SKU: CBMAB-C11602-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Rat, Human

Clone

CBLC220-LY

Antibody Isotype

IgG1

Application

Basic Information

Specificity

Rat, Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

FRA10A Associated CGG Repeat 1

Introduction

The protein encoded by this gene is a nuclear phosphoprotein of unknown function. This gene contains a tandem CGG repeat region within a CpG island that normally consists of 8-14 repeats but can expand to over 200 repeats. The repeat region is within the 5' UTR of some transcript variants, but is intronic to another variant. The expanded repeat allele is a fragile site and becomes hypermethylated, causing a reduction in gene expression. A disease phenotype has not been associated with expanded alleles. This gene is found within the rare FRA10A folate-sensitive fragile site. [provided by RefSeq, Dec 2016]

Entrez Gene ID

Human	118924
Rat	365458

UniProt ID

Human	Q70Z53
Rat	Q5FVF1

Biological Process

Dephosphorylation Source: GO_Central

Cellular Location

Nucleus

More Infomation

References

Sarafidou, T., Galliopoulou, E., Apostolopoulou, D., Fragkiadakis, G. A., & Moschonas, N. K. (2023). Reconstruction of a Comprehensive Interactome and Experimental Data Analysis of FRA10AC1 May Provide Insights into Its Biological Role in Health and Disease. Genes, 14(3), 568.

von Elsner, L., Chai, G., Schneeberger, P. E., Harms, F. L., Casar, C., Qi, M., ... & Kutsche, K. (2022). Biallelic FRA10AC1 variants cause a neurodevelopmental disorder with growth retardation. Brain, 145(4), 1551-1563.

Banka, S., Shalev, S., Park, S. M., Wood, K. A., Thomas, H. B., Wright, H. L., ... & O’Keefe, R. T. (2022). Bi-allelic FRA10AC1 variants in a multisystem human syndrome. Brain, 145(10), e86-e89.

Alsaleh, N., Alhashem, A., Tabarki, B., Mohamed, S., Alharby, E., Alkuraya, F. S., & Almontashiri, N. A. (2022). A Biallelic Variant in FRA10AC1 Is Associated With Neurodevelopmental Disorder and Growth Retardation. Neurology Genetics, 8(4).

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

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Mouse Anti-FRA10AC1 Recombinant Antibody (CBXF-3192)

Mouse Anti-FRA10AC1 Recombinant Antibody (CBXF-0900)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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