Mouse Anti-FRA10AC1 Recombinant Antibody (CBXF-0900) (CBMAB-F0470-CQ)

Name: Mouse Anti-FRA10AC1 Recombinant Antibody (CBXF-0900)
SKU: CBMAB-F0470-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-0900

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

FRA10A Associated CGG Repeat 1

Introduction

The protein encoded by this gene is a nuclear phosphoprotein of unknown function. This gene contains a tandem CGG repeat region within a CpG island that normally consists of 8-14 repeats but can expand to over 200 repeats. The repeat region is within the 5' UTR of some transcript variants, but is intronic to another variant. The expanded repeat allele is a fragile site and becomes hypermethylated, causing a reduction in gene expression. A disease phenotype has not been associated with expanded alleles. This gene is found within the rare FRA10A folate-sensitive fragile site.

Entrez Gene ID

118924

UniProt ID

Q70Z53

Alternative Names

FRA10A Associated CGG Repeat 1; Fragile Site, Folic Acid Type, Rare, Fra(10)(Q23.3) Or Fra(10)(Q24.2) Candidate 1; C10orf4; Rare Folic Acid-Type Fragile Site, FRA(10)(Q23.3), Candidate Gene 1; Chromosome 10 Open Reading Frame 4; Fragile Site 10q23.3; Protein FRA10AC1; F26C11.1-Like; FRA10A;

Biological Process

Dephosphorylation Source: GO_Central

Cellular Location

Nucleus

Sarafidou, T., Galliopoulou, E., Apostolopoulou, D., Fragkiadakis, G. A., & Moschonas, N. K. (2023). Reconstruction of a Comprehensive Interactome and Experimental Data Analysis of FRA10AC1 May Provide Insights into Its Biological Role in Health and Disease. Genes, 14(3), 568.

von Elsner, L., Chai, G., Schneeberger, P. E., Harms, F. L., Casar, C., Qi, M., ... & Kutsche, K. (2022). Biallelic FRA10AC1 variants cause a neurodevelopmental disorder with growth retardation. Brain, 145(4), 1551-1563.

Banka, S., Shalev, S., Park, S. M., Wood, K. A., Thomas, H. B., Wright, H. L., ... & O’Keefe, R. T. (2022). Bi-allelic FRA10AC1 variants in a multisystem human syndrome. Brain, 145(10), e86-e89.

Alsaleh, N., Alhashem, A., Tabarki, B., Mohamed, S., Alharby, E., Alkuraya, F. S., & Almontashiri, N. A. (2022). A Biallelic Variant in FRA10AC1 Is Associated With Neurodevelopmental Disorder and Growth Retardation. Neurology Genetics, 8(4).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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