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Rabbit Anti-FRAT1 Recombinant Antibody (CBXF-1184) (CBMAB-F0971-CQ)

This product is a rabbit antibody that recognizes Frat1. The antibody CBXF-1184 can be used for immunoassay techniques such as: WB, IP, ICC, FC.
See all FRAT1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXF-1184
Antibody Isotype
IgG
Application
WB, IP, ICC, FC

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
frequently rearranged in advanced T-cell lymphomas
Introduction
The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis.
Entrez Gene ID
Human10023
Mouse14296
Rat103691373
UniProt ID
HumanQ92837
MouseP70339
Alternative Names
FRAT1, WNT Signaling Pathway Regulator; Frequently Rearranged In Advanced T-Cell Lymphomas 1; FRAT-1; Frequently Rearranged In Advanced T-Cell Lymphomas; Proto-Oncogene FRAT1;
Function
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.
Biological Process
Canonical Wnt signaling pathway Source: WormBase
Positive regulation of canonical Wnt signaling pathway Source: WormBase
Cellular Location
Cytoplasm
PTM
Phosphorylated.

Tang, W., Pei, M., Li, J., Xu, N., Xiao, W., Yu, Z., ... & Wang, J. (2022). The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop modulates the metastasis and invasion of gastric cancer cells. Oncogene, 41(43), 4823-4838.

Nam, S. E., Ko, Y. S., Park, K. S., Jin, T., Yoo, Y. B., Yang, J. H., ... & Kim, W. S. (2022). Overexpression of FRAT1 protein is closely related to triple-negative breast cancer. Annals of Surgical Treatment and Research, 103(2), 63-71.

Yang, B., Liu, D., Ren, Y. Q., Sun, Y. Q., Zhang, J. P., Wang, X. G., ... & Guo, G. (2022). FRAT1 promotes the angiogenic properties of human glioblastoma cells via VEGFA. Molecular Medicine Reports, 25(3), 1-14.

Cai, X., Dai, Y., Gao, P., Ren, G., Cheng, D., Wang, B., ... & Xue, B. (2021). LncRNA CCAT1 promotes prostate cancer cells proliferation, migration, and invasion through regulation of miR-490-3p/FRAT1 axis. Aging (Albany NY), 13(14), 18527.

Li, X., & Zheng, H. (2020). LncRNA SNHG1 influences cell proliferation, migration, invasion, and apoptosis of non‐small cell lung cancer cells via the miR‐361‐3p/FRAT1 axis. Thoracic Cancer, 11(2), 295-304.

Guo, G., Liu, J., Ren, Y., Mao, X., Hao, Y., Zhong, C., ... & Zhao, Y. (2020). FRAT1 Enhances the Proliferation and Tumorigenesis of CD133+ Nestin+ Glioma Stem Cells In Vitro and In Vivo. Journal of Cancer, 11(9), 2421.

Xiao, S., Tang, H., Bai, Y., Zou, R., Ren, Z., Wu, X., ... & Wang, L. (2020). Swertiamarin suppresses proliferation, migration, and invasion of hepatocellular carcinoma cells via negative regulation of FRAT1. European Journal of Histochemistry: EJH, 64(4).

Zhang, X., Liu, W., & Wei, S. (2020). Luteolin affects keloid fibroblast proliferation and apoptosis by regulating FRAT1 gene expression. Cellular and Molecular Biology, 66(3), 185-190.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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