FRAT1

The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq]

Full Name

frequently rearranged in advanced T-cell lymphomas

Function

Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.

Biological Process

Canonical Wnt signaling pathway Source: WormBase
Positive regulation of canonical Wnt signaling pathway Source: WormBase

Cellular Location

Cytoplasm

PTM

Phosphorylated.

Anti-FRAT1 antibodies

Mouse Anti-FRAT1 Recombinant Antibody (CBXF-3193) (CBMAB-F3889-CQ)

Datasheet

SDS

Target: FRAT1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-3193

Application*: E, WB

Rabbit Anti-FRAT1 Recombinant Antibody (CBXF-1184) (CBMAB-F0971-CQ)

Datasheet

SDS

Target: FRAT1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBXF-1184

Application*: WB, IP, IC, F

Mouse Anti-FRAT1 Recombinant Antibody (7C9) (CBMAB-A3168-LY)

Datasheet

SDS

Target: FRAT1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 7C9

Application*: WB, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)