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Mouse Anti-FRK Recombinant Antibody (CBT3393) (V2LY-0625-LY2217)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3393
Antibody Isotype
IgG1
Application
IHC

Basic Information

Immunogen
Purified recombinant fragment of FRK (aa2-300) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fyn Related Src Family Tyrosine Kinase
Entrez Gene ID
2444
UniProt ID
P42685
Function
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Biological Process
Cell differentiation Source: GO_Central
Innate immune response Source: GO_Central
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Protein phosphorylation Source: ProtInc
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Cellular Location
Nucleus; Cytoplasm. Predominantly found in the nucleus, with a small fraction found in the cell periphery.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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