FRK

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]

Full Name

Fyn Related Src Family Tyrosine Kinase

Function

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

Biological Process

Cell differentiation Source: GO_Central
Innate immune response Source: GO_Central
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Protein phosphorylation Source: ProtInc
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central

Cellular Location

Nucleus; Cytoplasm. Predominantly found in the nucleus, with a small fraction found in the cell periphery.

Anti-FRK antibodies

Mouse Anti-FRK Recombinant Antibody (CBXF-1611) (CBMAB-F4139-CQ)

Datasheet

SDS

Target: FRK

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-1611

Application*: E, WB

Mouse Anti-FRK Recombinant Antibody (CBXF-1610) (CBMAB-F4138-CQ)

Datasheet

SDS

Target: FRK

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-1610

Application*: E, IH, WB

Rat Anti-FRK Recombinant Antibody (CBXF-2670) (CBMAB-F3080-CQ)

Datasheet

SDS

Target: FRK

Host: Rat

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-2670

Application*: IH

Rat Anti-FRK (AA 1-107) Recombinant Antibody (CBXF-0903) (CBMAB-F2474-CQ)

Datasheet

SDS

Target: FRK

Host: Rat

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-0903

Application*: E, IH

Mouse Anti-FRK Recombinant Antibody (7A7) (CBMAB-F1778-CQ)

Datasheet

SDS

Target: FRK

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 7A7

Application*: WB

Mouse Anti-FRK Recombinant Antibody (CBXF-3756) (CBMAB-F1741-CQ)

Datasheet

SDS

Target: FRK

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-3756

Application*: F, IH, P, WB

Mouse Anti-FRK Recombinant Antibody (5G4) (CBMAB-F1739-CQ)

Datasheet

SDS

Target: FRK

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5G4

Application*: F, IF, IH, P, WB

Mouse Anti-FRK Recombinant Antibody (1A8H2C12) (CBMAB-F1738-CQ)

Datasheet

SDS

Target: FRK

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1A8H2C12

Application*: E, P, WB

Mouse Anti-FRK Recombinant Antibody (5F3) (CBMAB-F1558-CQ)

Datasheet

SDS

Target: FRK

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5F3

Application*: F, IF

Mouse Anti-FRK Recombinant Antibody (3E2) (CBMAB-F1550-CQ)

Datasheet

SDS

Target: FRK

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3E2

Application*: F, IF, WB

Mouse Anti-FRK Recombinant Antibody (CBXF-0904) (CBMAB-F1286-CQ)

Datasheet

SDS

Target: FRK

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-0904

Application*: E, WB, P

Mouse Anti-FRK Recombinant Antibody (4E1) (CBMAB-F1048-CQ)

Datasheet

SDS

Target: FRK

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4E1

Application*: WB, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)