Rat Anti-FRK Recombinant Antibody (CBXF-2670) (CBMAB-F3080-CQ)

Name: Rat Anti-FRK Recombinant Antibody (CBXF-2670)
SKU: CBMAB-F3080-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rat

Clone

CBXF-2670

Application

IHC

Immunogen

E. coli-derived recombinant human Frk, Met1-Glu107, Accession # P42685

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

Lyophilized from a 0.2 μm filtered solution in PBS with trehalose

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fyn Related Src Family Tyrosine Kinase

Introduction

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.

Entrez Gene ID

2444

UniProt ID

P42685

Alternative Names

Fyn Related Src Family Tyrosine Kinase; Nuclear Tyrosine Protein Kinase RAK; PTK5 Protein Tyrosine Kinase 5; Protein-Tyrosine Kinase 5; Fyn-Related Kinase; EC 2.7.10.2; PTK5;

Function

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

Biological Process

Cell differentiation Source: GO_Central
Innate immune response Source: GO_Central
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Protein phosphorylation Source: ProtInc
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central

Cellular Location

Nucleus; Cytoplasm. Predominantly found in the nucleus, with a small fraction found in the cell periphery.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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