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Mouse Anti-FRK Recombinant Antibody (3E2) (CBMAB-F1550-CQ)

This product is a mouse antibody that recognizes FRK. The antibody 3E2 can be used for immunoassay techniques such as: FC, IF, WB.
See all FRK antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3E2
Antibody Isotype
IgG1
Application
FC, IF, WB

Basic Information

Immunogen
Full length recombinant protein of human FRK (NP_002022)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fyn Related Src Family Tyrosine Kinase
Introduction
The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.
Entrez Gene ID
UniProt ID
Alternative Names
Fyn Related Src Family Tyrosine Kinase; Nuclear Tyrosine Protein Kinase RAK; PTK5 Protein Tyrosine Kinase 5; Protein-Tyrosine Kinase 5; Fyn-Related Kinase; EC 2.7.10.2; PTK5;
Function
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Biological Process
Cell differentiation Source: GO_Central
Innate immune response Source: GO_Central
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Protein phosphorylation Source: ProtInc
Transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Cellular Location
Nucleus; Cytoplasm. Predominantly found in the nucleus, with a small fraction found in the cell periphery.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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