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Mouse Anti-FSCN2 Recombinant Antibody (CBXF-1802) (CBMAB-F3337-CQ)

This product is a mouse antibody that recognizes FSCN2. The antibody CBXF-1802 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all FSCN2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-1802
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fascin Actin-Bundling Protein 2, Retinal
Introduction
This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
25794
UniProt ID
O14926
Alternative Names
Fascin Actin-Bundling Protein 2, Retinal; Fascin (Strongylocentrotus Purpuratus) Homolog 2 (Actin-Bundling Protein, Retinal); Fascin Homolog 2, Actin-Bundling Protein, Retinal (Strongylocentrotus Purpuratus); Fascin Homolog 2, Actin-Bundling Protein, Retinal; Retinal Fascin; Fascin-2; RFSN; RP30;
Function
Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.
Biological Process
Actin cytoskeleton organization Source: UniProtKB
Actin filament bundle assembly Source: GO_Central
Anatomical structure morphogenesis Source: ProtInc
Cell migration Source: GO_Central
Establishment or maintenance of cell polarity Source: GO_Central
Eye photoreceptor cell development Source: Ensembl
Visual perception Source: ProtInc
Cellular Location
Cytoskeleton; Stereocilium
Involvement in disease
Retinitis pigmentosa 30 (RP30):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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