Mouse Anti-FSCN2 Recombinant Antibody (CBXF-1802) (CBMAB-F3337-CQ)

Name: Mouse Anti-FSCN2 Recombinant Antibody (CBXF-1802)
SKU: CBMAB-F3337-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-1802

Application

WB, IP, IF, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fascin Actin-Bundling Protein 2, Retinal

Introduction

This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

25794

UniProt ID

O14926

Alternative Names

Fascin Actin-Bundling Protein 2, Retinal; Fascin (Strongylocentrotus Purpuratus) Homolog 2 (Actin-Bundling Protein, Retinal); Fascin Homolog 2, Actin-Bundling Protein, Retinal (Strongylocentrotus Purpuratus); Fascin Homolog 2, Actin-Bundling Protein, Retinal; Retinal Fascin; Fascin-2; RFSN; RP30;

Function

Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.

Biological Process

Actin cytoskeleton organization Source: UniProtKB
Actin filament bundle assembly Source: GO_Central
Anatomical structure morphogenesis Source: ProtInc
Cell migration Source: GO_Central
Establishment or maintenance of cell polarity Source: GO_Central
Eye photoreceptor cell development Source: Ensembl
Visual perception Source: ProtInc

Cellular Location

Cytoskeleton; Stereocilium

Involvement in disease

Retinitis pigmentosa 30 (RP30):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

Gui, W., Nusinowitz, S., & Sarraf, D. (2018). Novel cone dystrophy with central ellipsoid zone loss associated with human retinal fascin gene (Fscn2) mutation. Retinal Cases and Brief Reports, 12, S63-S66.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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