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Mouse Anti-FSHR Monoclonal Antibody (FSHR/1400) (CBMAB-1284-YC)

Provided herein is a mouse monoclonal antibody against Human FSHR. The antibody, clone FSHR/1400, can be used for immunoassay techniques, such as IHC-P.
See all FSHR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
FSHR/1400
Antibody Isotype
IgG1
Application
IHC-P

Basic Information

Immunogen
Recombinant full length protein corresponding to Human FSH Receptor.
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Follicle Stimulating Hormone Receptor
Introduction
FSHR is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome.
Entrez Gene ID
2492
UniProt ID
P23945
Alternative Names
LGR1; ODG1; FSHR1; FSHRO
Function
G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546).

Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed:24058690).
Biological Process
Activation of adenylate cyclase activity Source: GO_Central
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
Cellular response to follicle-stimulating hormone stimulus Source: UniProtKB
Female gamete generation Source: ProtInc
Female gonad development Source: ProtInc
Follicle-stimulating hormone signaling pathway Source: UniProtKB
Gonad development Source: ProtInc
G protein-coupled receptor signaling pathway Source: UniProtKB
Hormone-mediated signaling pathway Source: GO_Central
Male gonad development Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
Regulation of protein kinase A signaling Source: UniProtKB
Spermatogenesis Source: ProtInc
Cellular Location
Cell membrane
Involvement in disease
Ovarian dysgenesis 1 (ODG1):
An autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, poorly developed streak ovaries, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Ovarian hyperstimulation syndrome (OHSS):
Disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis.
Topology
Extracellular: 18-366
Helical: 367-387
Cytoplasmic: 388-398
Helical: 399-421
Extracellular: 422-443
Helical: 444-465
Cytoplasmic: 466-485
Helical: 486-508
Extracellular: 509-528
Helical: 529-550
Cytoplasmic: 551-573
Helical: 574-597
Extracellular: 598-608
Helical: 609-630
Cytoplasmic: 631-695
PTM
Sulfated.
N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.

Duan, J., Xu, P., Zhang, H., Luan, X., Yang, J., He, X., ... & Xu, H. E. (2023). Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature Communications, 14(1), 519.

Surcel, M., Doroftei, B., Neamtiu, I. A., Muresan, D., Caracostea, G., Goidescu, I., ... & Zlatescu-Marton, C. (2022). Impact of Follicle Stimulating Hormone Receptor (FSHR) Polymorphism on the Efficiency of Co-Treatment with Growth Hormone in a Group of Infertile Women from Romania. Diagnostics, 12(10), 2371.

Xia, Y., Wang, Q., He, X. D., Chen, Y., JiGe, M. T., & Zi, X. D. (2020). Cloning and expression analysis of the follicle-stimulating hormone receptor (FSHR) gene in the reproductive axis of female yaks (Bos grunniens). Domestic animal endocrinology, 70, 106383.

Casarini, L., Lazzaretti, C., Paradiso, E., Limoncella, S., Riccetti, L., Sperduti, S., ... & Simoni, M. (2020). Membrane estrogen receptor (GPER) and follicle-stimulating hormone receptor (FSHR) heteromeric complexes promote human ovarian follicle survival. Iscience, 23(12), 101812.

Paschalidou, C., Anagnostou, E., Mavrogianni, D., Raouasnte, R., Klimis, N., Drakakis, P., & Loutradis, D. (2020). The effects of follicle-stimulating hormone receptor (FSHR)-29 and Ser680Asn polymorphisms in IVF/ICSI. Hormone Molecular Biology and Clinical Investigation, 41(2).

Laven, J. S. (2019). Follicle stimulating hormone receptor (FSHR) polymorphisms and polycystic ovary syndrome (PCOS). Frontiers in endocrinology, 10, 23.

Nenonen, H. A., Lindgren, I. A., Prahl, A. S., Trzybulska, D., Kharraziha, I., Hultén, M., ... & Henic, E. (2019). The N680S variant in the follicle-stimulating hormone receptor gene identifies hyperresponders to controlled ovarian stimulation. Pharmacogenetics and Genomics, 29(5), 114.

Nataraja, S., Sriraman, V., & Palmer, S. (2018). Allosteric regulation of the follicle-stimulating hormone receptor. Endocrinology, 159(7), 2704-2716.

Ulloa-Aguirre, A., Zariñán, T., Jardón-Valadez, E., Gutiérrez-Sagal, R., & Dias, J. A. (2018). Structure-function relationships of the follicle-stimulating hormone receptor. Frontiers in endocrinology, 9, 707.

Kim, D., & Johnson, A. L. (2018). Differentiation of the granulosa layer from hen prehierarchal follicles associated with follicle‐stimulating hormone receptor signaling. Molecular reproduction and development, 85(8-9), 729-737.

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For research use only. Not intended for any clinical use.

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