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Mouse Anti-FTCD Recombinant Antibody (58K-9) (CBMAB-1917CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Dog, Pig, Rat, Hamster, Cattle
Clone
58K-9
Antibody Isotype
IgG1
Application
EM, IF, IHC, IHC-P, WB

Basic Information

Immunogen
Full length native protein (purified) (Rat liver)
Specificity
Human, Dog, Pig, Rat, Hamster, Cattle
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
formiminotransferase cyclodeaminase
Introduction
The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
Human10841
Hamster100754097
Rat89833
Dog607685
Cattle535816
Pig397517
UniProt ID
HumanO95954
HamsterA0A1U7QC44
RatO88618
DogF1PFK5
CattleA0A3Q1MBB6
PigP53603
Alternative Names
LCHC1
Function
Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.

Binds and promotes bundling of vimentin filaments originating from the Golgi.
Biological Process
Cytoskeleton organization Source: Ensembl
Folic acid-containing compound metabolic process Source: ProtInc
Histidine catabolic process to glutamate and formamide Source: UniProtKB-UniPathway
Histidine catabolic process to glutamate and formate Source: UniProtKB-UniPathway
Tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Cellular Location
Golgi apparatus; Centriole. More abundantly located around the mother centriole.
Involvement in disease
Glutamate formiminotransferase deficiency (FIGLU-URIA):
Autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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