FTCD
FTCD is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool.[supplied by OMIM
Full Name
formiminotransferase cyclodeaminase
Function
Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.
Binds and promotes bundling of vimentin filaments originating from the Golgi.
Binds and promotes bundling of vimentin filaments originating from the Golgi.
Biological Process
Cytoskeleton organization Source: Ensembl
Folic acid-containing compound metabolic process Source: ProtInc
Histidine catabolic process to glutamate and formamide Source: UniProtKB-UniPathway
Histidine catabolic process to glutamate and formate Source: UniProtKB-UniPathway
Tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Folic acid-containing compound metabolic process Source: ProtInc
Histidine catabolic process to glutamate and formamide Source: UniProtKB-UniPathway
Histidine catabolic process to glutamate and formate Source: UniProtKB-UniPathway
Tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Cellular Location
Golgi apparatus; Centriole. More abundantly located around the mother centriole.
Involvement in disease
Glutamate formiminotransferase deficiency (FIGLU-URIA):
Autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities.
Autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities.
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Anti-FTCD antibodies
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CompareTarget: FTCD
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5F6
Application*: WB, E, IF, IH
Target: FTCD
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-3216
Application*: WB, P, F
Target: FTCD
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-3215
Application*: E, IF, IH, WB
Target: FTCD
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human, Dog
Clone: CBXF-1804
Application*: WB, IP, IF, P, E
Target: FTCD
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1803
Application*: WB, IP, IF, E
Target: FTCD
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0940
Application*: SE, E, WB, IF, P
Target: FTCD
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-1274
Application*: IH
Target: FTCD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1273
Application*: IH
Target: FTCD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBXF-0942
Application*: IF, IH, WB
Target: FTCD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3592
Application*: WB
Target: FTCD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3561
Application*: P, WB
Target: FTCD
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-0941
Application*: WB, IH, F
Target: FTCD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 187
Application*: WB, IP, IF, E
Target: FTCD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: UMAB122
Application*: P
Target: FTCD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBLQ5-058
Application*: IC, IF, IH, WB
Target: FTCD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 8F12
Application*: WB, IP, IF, E
Target: FTCD
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 8C2
Application*: P, WB
Target: FTCD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 7C5
Application*: WB, IP, IF, E, P
Target: FTCD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Pig, Rat, Hamster, Cattle
Clone: 58K-9
Application*: EM, IF, IH, P, WB
Target: FTCD
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 575
Application*: WB, P
Target: FTCD
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4A7
Application*: P, WB
Target: FTCD
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3A4
Application*: E, IF, P, WB
Target: FTCD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B12
Application*: WB
Target: FTCD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A7
Application*: P, WB
Target: FTCD
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-541
Tag: His Tag
Target: FTCD
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBXF-0940
Application*: WB, IP
Target: FTCD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1274
Application*: WB
Target: FTCD
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-1273
Application*: WB, IH
Target: FTCD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBXF-0942
Application*: WB, F
Target: FTCD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3592
Application*: WB, IF, F
Target: FTCD
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-3561
Application*: WB, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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