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Mouse Anti-FTCD Recombinant Antibody (CBXF-1804) (CBMAB-F3339-CQ)

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Basic Information

Host Animal
Mouse
Clone
CBXF-1804
Application
WB, IP, IF, IHC-P, ELISA
Specificity
Mouse, Rat, Human, Dog
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
formiminotransferase cyclodeaminase
Introduction
The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
Human10841
Mouse14317
Rat89833
Dog607685
UniProt ID
HumanO95954
MouseQ91XD4
RatO88618
DogF1PFK5
Alternative Names
Formimidoyltransferase Cyclodeaminase; Formiminotransferase-Cyclodeaminase; LCHC1; Formimidoyltransferase-Cyclodeaminase; Formiminotransferase Cyclodeaminase;
Function
Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.

Binds and promotes bundling of vimentin filaments originating from the Golgi.
Biological Process
Cytoskeleton organization Source: Ensembl
Folic acid-containing compound metabolic process Source: ProtInc
Histidine catabolic process to glutamate and formamide Source: UniProtKB-UniPathway
Histidine catabolic process to glutamate and formate Source: UniProtKB-UniPathway
Tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Cellular Location
Golgi apparatus; Centriole. More abundantly located around the mother centriole.
Involvement in disease
Glutamate formiminotransferase deficiency (FIGLU-URIA):
Autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities.

Chen, J., Yang, Y., Lin, B., Xu, Z., Yang, X., Ye, S., ... & Huang, W. (2022). Hollow mesoporous organosilica nanotheranostics incorporating formimidoyltransferase cyclodeaminase (FTCD) plasmids for magnetic resonance imaging and tetrahydrofolate metabolism fission on hepatocellular carcinoma. International Journal of Pharmaceutics, 612, 121281.

Zhang, W., Wu, C., Ni, R., Yang, Q., Luo, L., & He, J. (2021). Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1. PLoS Genetics, 17(12), e1009980.

Greenwood, P. M., Schmidt, K., Lin, M. K., Lipsky, R., Parasuraman, R., & Jankord, R. (2018). A functional promoter variant of the human formimidoyltransferase cyclodeaminase (FTCD) gene is associated with working memory performance in young but not older adults. Neuropsychology, 32(8), 973.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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