Mouse Anti-FTCD Recombinant Antibody (CBXF-0942) (V2LY-1225-LY191)

Name: Mouse Anti-FTCD Recombinant Antibody (CBXF-0942)
SKU: V2LY-1225-LY191
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-0942

Application

WB, FC

Immunogen

Full length human recombinant protein of human FTCD.

Host Species

Mouse

Specificity

Human, Monkey

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

Application	Note
WB	1:500-1:2,000
FC	1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, BSA, glycerol

Preservative

Sodium azide

Concentration

1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

formiminotransferase cyclodeaminase

Entrez Gene ID

10841

UniProt ID

O95954

Function

Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.

Binds and promotes bundling of vimentin filaments originating from the Golgi.

Biological Process

Cytoskeleton organization Source: Ensembl
Folic acid-containing compound metabolic process Source: ProtInc
Histidine catabolic process to glutamate and formamide Source: UniProtKB-UniPathway
Histidine catabolic process to glutamate and formate Source: UniProtKB-UniPathway
Tetrahydrofolate interconversion Source: UniProtKB-UniPathway

Cellular Location

Golgi apparatus; Centriole. More abundantly located around the mother centriole.

Involvement in disease

Glutamate formiminotransferase deficiency (FIGLU-URIA):
Autosomal recessive disorder. Features of a severe phenotype, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. Features of a mild phenotype include high urinary excretion of FIGLU in the absence of histidine administration, mild developmental delay, and no hematological abnormalities.

Chen, J., Yang, Y., Lin, B., Xu, Z., Yang, X., Ye, S., ... & Huang, W. (2022). Hollow mesoporous organosilica nanotheranostics incorporating formimidoyltransferase cyclodeaminase (FTCD) plasmids for magnetic resonance imaging and tetrahydrofolate metabolism fission on hepatocellular carcinoma. International Journal of Pharmaceutics, 612, 121281.

Zhang, W., Wu, C., Ni, R., Yang, Q., Luo, L., & He, J. (2021). Formimidoyltransferase cyclodeaminase prevents the starvation-induced liver hepatomegaly and dysfunction through downregulating mTORC1. PLoS Genetics, 17(12), e1009980.

Greenwood, P. M., Schmidt, K., Lin, M. K., Lipsky, R., Parasuraman, R., & Jankord, R. (2018). A functional promoter variant of the human formimidoyltransferase cyclodeaminase (FTCD) gene is associated with working memory performance in young but not older adults. Neuropsychology, 32(8), 973.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-FTCD Recombinant Antibody (CBXF-0942) (CAT#: CBMAB-F2487-CQ)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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