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Mouse Anti-FTMT Recombinant Antibody (6G3) (CBMAB-A3217-LY)

The product is antibody recognizes FTMT. The antibody 6G3 immunoassay techniques such as: WB, ELISA.
See all FTMT antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6G3
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
FTMT (NP_803431.1, 143 a.a. ~ 242 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ferritin mitochondrial
Entrez Gene ID
94033
UniProt ID
Q8N4E7
Alternative Names
MTF
Function
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
Biological Process
Cellular iron ion homeostasis Source: BHF-UCL
Intracellular sequestering of iron ion Source: GO_Central
Iron ion transport Source: InterPro
Positive regulation of aconitate hydratase activity Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of lyase activity Source: BHF-UCL
Positive regulation of succinate dehydrogenase activity Source: BHF-UCL
Cellular Location
Mitochondrion

Fuhrmann, D. C., Becker, S., & Brüne, B. (2023). Mitochondrial ferritin expression in human macrophages is facilitated by thrombin‐mediated cleavage under hypoxia. FEBS letters, 597(2), 276-287.

Wang, X., Ma, H., Sun, J., Zheng, T., Zhao, P., Li, H., & Yang, M. (2022). Mitochondrial ferritin deficiency promotes osteoblastic ferroptosis via mitophagy in type 2 diabetic osteoporosis. Biological trace element research, 1-10.

Wang, P., Cui, Y., Liu, Y., Li, Z., Bai, H., Zhao, Y., & Chang, Y. Z. (2022). Mitochondrial ferritin alleviates apoptosis by enhancing mitochondrial bioenergetics and stimulating glucose metabolism in cerebral ischemia reperfusion. Redox Biology, 57, 102475.

Wang, P., Ren, Q., Shi, M., Liu, Y., Bai, H., & Chang, Y. Z. (2022). Overexpression of Mitochondrial Ferritin Enhances Blood–Brain Barrier Integrity following Ischemic Stroke in Mice by Maintaining Iron Homeostasis in Endothelial Cells. Antioxidants, 11(7), 1257.

Wang, P., Cui, Y., Ren, Q., Yan, B., Zhao, Y., Yu, P., ... & Chang, Y. Z. (2021). Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis. Cell death & disease, 12(5), 447.

Levi, S., Ripamonti, M., Dardi, M., Cozzi, A., & Santambrogio, P. (2021). Mitochondrial ferritin: Its role in physiological and pathological conditions. Cells, 10(8), 1969.

Fuhrmann, D. C., Mondorf, A., Beifuß, J., Jung, M., & Brüne, B. (2020). Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis. Redox biology, 36, 101670.

Hara, Y., Yanatori, I., Tanaka, A., Kishi, F., Lemasters, J. J., Nishina, S., ... & Hino, K. (2020). Iron loss triggers mitophagy through induction of mitochondrial ferritin. EMBO reports, 21(11), e50202.

Wu, Q., Wu, W. S., Su, L., Zheng, X., Wu, W. Y., Santambrogio, P., ... & Chang, Y. Z. (2019). Mitochondrial ferritin is a hypoxia-inducible factor 1α-inducible gene that protects from hypoxia-induced cell death in brain. Antioxidants & redox signaling, 30(2), 198-212.

Mendsaikhan, A., Takeuchi, S., Walker, D. G., & Tooyama, I. (2019). Differences in gene expression profiles and phenotypes of differentiated SH-SY5Y neurons stably overexpressing mitochondrial ferritin. Frontiers in molecular neuroscience, 11, 470.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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