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Mouse Anti-FUBP1 Recombinant Antibody (CBXF-0006) (CBMAB-F3219-CQ)

This product is a mouse antibody that recognizes FUBP1. The antibody CBXF-0006 can be used for immunoassay techniques such as: ELISA, WB.
See all FUBP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0006
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
FUBP1 (NP_003893, 27 a.a.-136 a.a) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
far upstream element (FUSE) binding protein 1
Introduction
The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
8880
UniProt ID
Q96AE4
Alternative Names
Far Upstream Element Binding Protein 1; Far Upstream Element (FUSE) Binding Protein 1; FUSE Binding Protein 1; DNA Helicase V; HDH V; FBP; Far Upstream Element-Binding Protein 1; FUSE-Binding Protein 1; FUBP;
Function
Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.
Biological Process
Positive regulation of gene expression Source: UniProtKB
Regulation of gene expression Source: GO_Central
Cellular Location
Nucleus
PTM
Ubiquitinated. This targets the protein for proteasome-mediated degradation.

Yin, H., Gao, T., Xie, J., Huang, Z., Zhang, X., Yang, F., ... & Yang, X. (2021). FUBP1 promotes colorectal cancer stemness and metastasis via DVL1‐mediated activation of Wnt/β‐catenin signaling. Molecular Oncology, 15(12), 3490-3512.

Wang, X., Xing, L., Yang, R., Chen, H., Wang, M., Jiang, R., ... & Chen, J. (2021). The circACTN4 interacts with FUBP1 to promote tumorigenesis and progression of breast cancer by regulating the expression of proto-oncogene MYC. Molecular Cancer, 20(1), 1-21.

Qian, X., Yang, J., Qiu, Q., Li, X., Jiang, C., Li, J., ... & Lu, Y. (2021). LCAT3, a novel m6A-regulated long non-coding RNA, plays an oncogenic role in lung cancer via binding with FUBP1 to activate c-MYC. Journal of hematology & oncology, 14, 1-19.

Han, T., Wu, Y., Hu, X., Chen, Y., Jia, W., He, Q., ... & Wan, X. (2020). NORAD orchestrates endometrial cancer progression by sequestering FUBP1 nuclear localization to promote cell apoptosis. Cell Death & Disease, 11(6), 473.

Kang, M., Kim, H. J., Kim, T. J., Byun, J. S., Lee, J. H., Lee, D. H., ... & Kim, D. Y. (2020). Multiple functions of Fubp1 in cell cycle progression and cell survival. Cells, 9(6), 1347.

Debaize, L., & Troadec, M. B. (2019). The master regulator FUBP1: its emerging role in normal cell function and malignant development. Cellular and Molecular Life Sciences, 76, 259-281.

Hoang, V. T., Verma, D., Godavarthy, P. S., Llavona, P., Steiner, M., Gerlach, K., ... & Krause, D. S. (2019). The transcriptional regulator FUBP1 influences disease outcome in murine and human myeloid leukemia. Leukemia, 33(7), 1700-1712.

Elman, J. S., Ni, T. K., Mengwasser, K. E., Jin, D., Wronski, A., Elledge, S. J., & Kuperwasser, C. (2019). Identification of FUBP1 as a long tail cancer driver and widespread regulator of tumor suppressor and oncogene alternative splicing. Cell reports, 28(13), 3435-3449.

Jiang, P., Huang, M., Qi, W., Wang, F., Yang, T., Gao, T., ... & Yang, X. (2019). FUBP1 promotes neuroblastoma proliferation via enhancing glycolysis-a new possible marker of malignancy for neuroblastoma. Journal of Experimental & Clinical Cancer Research, 38(1), 1-19.

Debaize, L., Jakobczyk, H., Avner, S., Gaudichon, J., Rio, A. G., Sérandour, A. A., ... & Troadec, M. B. (2018). Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation. Nucleic Acids Research, 46(21), 11214-11228.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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