Mouse Anti-FUCA2 Recombinant Antibody (CBXF-3233) (CBMAB-F3928-CQ)

Name: Mouse Anti-FUCA2 Recombinant Antibody (CBXF-3233)
SKU: CBMAB-F3928-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-3233

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa368-466 from human FUCA2 (NP_114409) with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

fucosidase, alpha-L- 2, plasma

Introduction

This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells.

Entrez Gene ID

2519

UniProt ID

Q9BTY2

Alternative Names

Alpha-L-Fucosidase 2; Alpha-L-Fucoside Fucohydrolase 2; Fucosidase, Alpha-L- 2, Plasma; Plasma Fucosidase; A-L-Fucosidase 2; EC 3.2.1.51; Plasma Alpha-L-Fucosidase; DJ20N2.5;

Function

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Biological Process

Fucose metabolic process Source: UniProtKB
Glycoside catabolic process Source: UniProtKB
Regulation of entry of bacterium into host cell Source: UniProtKB
Response to bacterium Source: UniProtKB

Cellular Location

Secreted

Liu, Q., Dong, H. T., Zhao, T., Yao, F., Xu, Y., Chen, B., ... & Xing, P. (2022). Cancer-associated adipocytes release FUCA2 to promote aggressiveness in TNBC. Endocrine-Related Cancer, 29(3), 139-149.

Quirino, M. W. L., de Barros Albuquerque, A. P., de Souza, M. D. F. D., da Silva Filho, A. F., Martins, M. R., da Rocha Pitta, M. G., ... & de Melo, M. J. B. (2022). FUCA2 and TSTA3 expression in gastric cancer: candidate biomarkers of malignant transformation. Folia Histochemica et Cytobiologica, 60(4), 335-343.

Zhong, A., Chen, T., Xing, Y., Pan, X., & Shi, M. (2021). FUCA2 is a prognostic biomarker and correlated with an immunosuppressive microenvironment in pan-cancer. Frontiers in immunology, 12, 758648.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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