Mouse Anti-FUT2 Recombinant Antibody (CBXF-1450) (CBMAB-F4154-CQ)

Name: Mouse Anti-FUT2 Recombinant Antibody (CBXF-1450)
SKU: CBMAB-F4154-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-1450

Application

ELISA, WB

Immunogen

Partial Recombinant protein corresponding to aa51-150 of human FUT2 (NP_000502), with a GST tag. MW of GST tag alone is 26kD

Specificity

Human, Mouse

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

fucosyltransferase 2 (secretor status included)

Introduction

The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene.

Entrez Gene ID

Human	2524
Mouse	14344

UniProt ID

Human	Q10981
Mouse	Q9JL27

Alternative Names

Fucosyltransferase 2; GDP-L-Fucose:Beta-D-Galactoside 2-Alpha-L-Fucosyltransferase 2; Secretor Blood Group Alpha-2-Fucosyltransferase; Secretor Factor; Fucosyltransferase 2 (Secretor Status Included); Galactoside 2-Alpha-L-Fucosyltransferase 2; Alpha (1,2) Fucosyltransferase; Alpha(1,2)FT 2; Alpha(1,2)FT2;

Function

Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:7876235, PubMed:8018146, PubMed:12692541).

Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (By similarity).

Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PubMed:22068912, PubMed:21625510, PubMed:24733310).

Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235).

Biological Process

Carbohydrate metabolic process Source: ProtInc
Fucosylation Source: UniProtKB
Glycolipid metabolic process Source: UniProtKB
L-fucose catabolic process Source: UniProtKB
Oligosaccharide biosynthetic process Source: Reactome
Protein glycosylation Source: GO_Central
Regulation of cell adhesion Source: UniProtKB
Regulation of endothelial cell proliferation Source: UniProtKB

Cellular Location

Golgi stack membrane. Membrane-bound form in trans cisternae of Golgi.

Topology

Cytoplasmic: 1-14
Helical: 15-28
Lumenal: 29-343

Soejima, M., & Koda, Y. (2023). Estimation of Lewis Blood Group Status by Fluorescence Melting Curve Analysis in Simultaneous Genotyping of c. 385A> T and Fusion Gene in FUT2 and c. 59T> G and c. 314C> T in FUT3. Diagnostics, 13(5), 931.

Kaur, P., Gupta, M., & Sagar, V. (2022). FUT2 gene as a genetic susceptible marker of infectious diseases: A Review. International Journal of Molecular Epidemiology and Genetics, 13(1), 1.

Rattanapan, Y., Charong, N., Narkpetch, S., & Chareonsirisuthigul, T. (2022). Genotyping of the rare Para-Bombay blood group in southern Thailand. Hematology, Transfusion and Cell Therapy.

Lin, H. Y., Lai, H. H., Chen, Y. F. E., Chao, H. C., Tsai, C. N., Chang, Y. J., & Chen, S. Y. (2021). Clinical significance of the fucosyltransferase 2 (FUT2) secretor status in children hospitalized with acute gastroenteritis in Taiwan. Journal of the Formosan Medical Association, 120(1), 212-216.

Galeev, A., Suwandi, A., Cepic, A., Basu, M., Baines, J. F., & Grassl, G. A. (2021). The role of the blood group-related glycosyltransferases FUT2 and B4GALNT2 in susceptibility to infectious disease. International Journal of Medical Microbiology, 311(3), 151487.

Ye, B. D., Kim, B. M., Jung, S., Lee, H. S., Hong, M., Kim, K., ... & Song, K. (2020). Association of FUT2 and ABO with Crohn's disease in Koreans. Journal of Gastroenterology and Hepatology, 35(1), 104-109.

Haga, K., Ettayebi, K., Tenge, V. R., Karandikar, U. C., Lewis, M. A., Lin, S. C., ... & Estes, M. K. (2020). Genetic manipulation of human intestinal enteroids demonstrates the necessity of a functional fucosyltransferase 2 gene for secretor-dependent human norovirus infection. MBio, 11(2), e00251-20.

Soejima, M., & Koda, Y. (2020). FUT2 polymorphism in Latin American populations. Clinica Chimica Acta, 505, 1-5.

Scharberg, E. A., Olsen, C., & Bugert, P. (2019). An update on the H blood group system. Immunohematology, 35(2), 67-68.

Pérez-Ortín, R., Vila-Vicent, S., Carmona-Vicente, N., Santiso-Bellón, C., Rodríguez-Díaz, J., & Buesa, J. (2019). Histo-blood group antigens in children with symptomatic rotavirus infection. Viruses, 11(4), 339.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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