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Mouse Anti-FUT2 Recombinant Antibody (CBXF-3590) (CBMAB-F2352-CQ)

This product is a mouse antibody that recognizes FUT2. The antibody CBXF-3590 can be used for immunoassay techniques such as: ELISA, WB.
See all FUT2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-3590
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
fucosyltransferase 2 (secretor status included)
Introduction
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene.
Entrez Gene ID
2524
UniProt ID
Q10981
Alternative Names
Fucosyltransferase 2; GDP-L-Fucose:Beta-D-Galactoside 2-Alpha-L-Fucosyltransferase 2; Secretor Blood Group Alpha-2-Fucosyltransferase; Secretor Factor; Fucosyltransferase 2 (Secretor Status Included); Galactoside 2-Alpha-L-Fucosyltransferase 2; Alpha (1,2) Fucosyltransferase; Alpha(1,2)FT 2; Alpha(1,2)FT2;
Function
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:7876235, PubMed:8018146, PubMed:12692541).

Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (By similarity).

Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PubMed:22068912, PubMed:21625510, PubMed:24733310).

Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235).
Biological Process
Carbohydrate metabolic process Source: ProtInc
Fucosylation Source: UniProtKB
Glycolipid metabolic process Source: UniProtKB
L-fucose catabolic process Source: UniProtKB
Oligosaccharide biosynthetic process Source: Reactome
Protein glycosylation Source: GO_Central
Regulation of cell adhesion Source: UniProtKB
Regulation of endothelial cell proliferation Source: UniProtKB
Cellular Location
Golgi stack membrane. Membrane-bound form in trans cisternae of Golgi.
Topology
Cytoplasmic: 1-14
Helical: 15-28
Lumenal: 29-343

Soejima, M., & Koda, Y. (2023). Estimation of Lewis Blood Group Status by Fluorescence Melting Curve Analysis in Simultaneous Genotyping of c. 385A> T and Fusion Gene in FUT2 and c. 59T> G and c. 314C> T in FUT3. Diagnostics, 13(5), 931.

Kaur, P., Gupta, M., & Sagar, V. (2022). FUT2 gene as a genetic susceptible marker of infectious diseases: A Review. International Journal of Molecular Epidemiology and Genetics, 13(1), 1.

Rattanapan, Y., Charong, N., Narkpetch, S., & Chareonsirisuthigul, T. (2022). Genotyping of the rare Para-Bombay blood group in southern Thailand. Hematology, Transfusion and Cell Therapy.

Lin, H. Y., Lai, H. H., Chen, Y. F. E., Chao, H. C., Tsai, C. N., Chang, Y. J., & Chen, S. Y. (2021). Clinical significance of the fucosyltransferase 2 (FUT2) secretor status in children hospitalized with acute gastroenteritis in Taiwan. Journal of the Formosan Medical Association, 120(1), 212-216.

Galeev, A., Suwandi, A., Cepic, A., Basu, M., Baines, J. F., & Grassl, G. A. (2021). The role of the blood group-related glycosyltransferases FUT2 and B4GALNT2 in susceptibility to infectious disease. International Journal of Medical Microbiology, 311(3), 151487.

Ye, B. D., Kim, B. M., Jung, S., Lee, H. S., Hong, M., Kim, K., ... & Song, K. (2020). Association of FUT2 and ABO with Crohn's disease in Koreans. Journal of Gastroenterology and Hepatology, 35(1), 104-109.

Haga, K., Ettayebi, K., Tenge, V. R., Karandikar, U. C., Lewis, M. A., Lin, S. C., ... & Estes, M. K. (2020). Genetic manipulation of human intestinal enteroids demonstrates the necessity of a functional fucosyltransferase 2 gene for secretor-dependent human norovirus infection. MBio, 11(2), e00251-20.

Soejima, M., & Koda, Y. (2020). FUT2 polymorphism in Latin American populations. Clinica Chimica Acta, 505, 1-5.

Scharberg, E. A., Olsen, C., & Bugert, P. (2019). An update on the H blood group system. Immunohematology, 35(2), 67-68.

Pérez-Ortín, R., Vila-Vicent, S., Carmona-Vicente, N., Santiso-Bellón, C., Rodríguez-Díaz, J., & Buesa, J. (2019). Histo-blood group antigens in children with symptomatic rotavirus infection. Viruses, 11(4), 339.

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For research use only. Not intended for any clinical use.

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