Mouse Anti-FUT9 Recombinant Antibody (CBXF-2542) (V2LY-1225-LY311)

Name: Mouse Anti-FUT9 Recombinant Antibody (CBXF-2542)
SKU: V2LY-1225-LY311
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-2542

Application

WB, ELISA, IHC

Immunogen

Recombinant human FUT9.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fucosyltransferase 9

Entrez Gene ID

10690

UniProt ID

Q9Y231

Function

Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal lactosamine unit of a glycoprotein or a glycolipid-linked polylactosamine chains through an alpha-1,3 glycosidic linkage and participates in particular to the Lewis x (Lex)/CD15 epitope biosynthesis in neurons which allows cell differentiation, cell adhesion, and initiation of neurite outgrowth (PubMed:23263199, PubMed:23192350, PubMed:10386598, PubMed:17335083, PubMed:23000574, PubMed:11278338, PubMed:10622713, PubMed:18395013, PubMed:12107078, PubMed:16282604).

Also fucosylates di-, tri- and tetraantennary N-glycans linked to glycoproteins and the inner lactosamine unit of the alpha2,3-sialylated polylactosamine resulting in sLex (CD15s) epitope synthesis (PubMed:11278338, PubMed:12107078, PubMed:18395013).

Furthermore, it is capable of synthesizing Lewis a (Lea), although to a lesser extent than Lex and Lewis y (Ley) and to confer SELE-dependent, but not SELL- and SELP-selectin-dependent, cell rolling and adhesion by enhancing Lex and sLex synthesis (PubMed:18395013, PubMed:23192350).

Biological Process

Carbohydrate metabolic process Source: ProtInc
Cellular polysaccharide biosynthetic process Source: UniProtKB
Fucosylation Source: UniProtKB
L-fucose catabolic process Source: UniProtKB
Neuron differentiation Source: UniProtKB
Oligosaccharide biosynthetic process Source: Reactome
Positive regulation of neuron projection development Source: UniProtKB
Protein glycosylation Source: UniProtKB
Regulation of leukocyte cell-cell adhesion Source: UniProtKB
Regulation of leukocyte tethering or rolling Source: UniProtKB

Cellular Location

Trans-Golgi network membrane; Golgi apparatus membrane

Topology

Cytoplasmic: 1-11
Helical: 12-32
Lumenal: 33-359

PTM

N-glycosylated with complex-type N-glycans.

Chaubey, S., Nader, Y. M., Shah, D., Kumova, O. K., Prahaladan, V., Carey, A. J., ... & Bhandari, V. (2021). α1, 3-Fucosyltransferase-IX, an enzyme of pulmonary endogenous lung stem cell marker SSEA-1, alleviates experimental bronchopulmonary dysplasia. Pediatric Research, 89(5), 1126-1135.

Fan, R., Han, X., Gong, Y., He, L., Xue, Z., Yang, Y., ... & Zhang, J. (2021). Alterations of fucosyltransferase genes and fucosylated glycans in gastric epithelial cells infected with Helicobacter pylori. Pathogens, 10(2), 168.

Blanas, A., Cornelissen, L. A., Kotsias, M., van der Horst, J. C., van de Vrugt, H. J., Kalay, H., ... & van Vliet, S. J. (2019). Transcriptional activation of fucosyltransferase (FUT) genes using the CRISPR-dCas9-VPR technology reveals potent N-glycome alterations in colorectal cancer cells. Glycobiology, 29(2), 137-150.

Shan, M., Yang, D., Dou, H., & Zhang, L. (2019). Fucosylation in cancer biology and its clinical applications. Progress in molecular biology and translational science, 162, 93-119.

Cho, E. H., Soliman, M., Alfajaro, M. M., Kim, J. Y., Seo, J. Y., Park, J. G., ... & Cho, K. O. (2018). Bovine nebovirus interacts with a wide spectrum of histo-blood group antigens. Journal of Virology, 92(9), e02160-17.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-FUT9 Recombinant Antibody (CBXF-2542) (CAT#: CBMAB-F1597-CQ)

Related Products

Mouse Anti-FUT9 Recombinant Antibody (CBXF-2542) (CAT#: CBMAB-F1597-CQ)

Mouse Anti-FUT9 Recombinant Antibody (650) (CAT#: CBMAB-AP2420LY)

Mouse Anti-FUT9 Recombinant Antibody (CF177) (CAT#: CBMAB-FT311LY)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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