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Mouse Anti-FUT9 Recombinant Antibody (CF177) (CBMAB-FT311LY)

The product is antibody recognizes FUT9 . The antibody CF177 immunoassay techniques such as: ELISA, WB, IHC.
See all FUT9 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CF177
Antibody Isotype
IgG1
Application
ELISA, WB, IHC

Basic Information

Immunogen
fucosyltransferase 9 (alpha (1, 3) fucosyltransferase)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Fucosyltransferase 9
Introduction
The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011]
Entrez Gene ID
10690
UniProt ID
Q9Y231
Function
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal lactosamine unit of a glycoprotein or a glycolipid-linked polylactosamine chains through an alpha-1,3 glycosidic linkage and participates in particular to the Lewis x (Lex)/CD15 epitope biosynthesis in neurons which allows cell differentiation, cell adhesion, and initiation of neurite outgrowth (PubMed:23263199, PubMed:23192350, PubMed:10386598, PubMed:17335083, PubMed:23000574, PubMed:11278338, PubMed:10622713, PubMed:18395013, PubMed:12107078, PubMed:16282604).

Also fucosylates di-, tri- and tetraantennary N-glycans linked to glycoproteins and the inner lactosamine unit of the alpha2,3-sialylated polylactosamine resulting in sLex (CD15s) epitope synthesis (PubMed:11278338, PubMed:12107078, PubMed:18395013).

Furthermore, it is capable of synthesizing Lewis a (Lea), although to a lesser extent than Lex and Lewis y (Ley) and to confer SELE-dependent, but not SELL- and SELP-selectin-dependent, cell rolling and adhesion by enhancing Lex and sLex synthesis (PubMed:18395013, PubMed:23192350).
Biological Process
Carbohydrate metabolic process Source: ProtInc
Cellular polysaccharide biosynthetic process Source: UniProtKB
Fucosylation Source: UniProtKB
L-fucose catabolic process Source: UniProtKB
Neuron differentiation Source: UniProtKB
Oligosaccharide biosynthetic process Source: Reactome
Positive regulation of neuron projection development Source: UniProtKB
Protein glycosylation Source: UniProtKB
Regulation of leukocyte cell-cell adhesion Source: UniProtKB
Regulation of leukocyte tethering or rolling Source: UniProtKB
Cellular Location
Trans-Golgi network membrane; Golgi apparatus membrane
Topology
Cytoplasmic: 1-11
Helical: 12-32
Lumenal: 33-359
PTM
N-glycosylated with complex-type N-glycans.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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