Sign in or Register   Sign in or Register
  |  

Mouse Anti-GABRA4 Recombinant Antibody (S398A-34) (CBMAB-AP2438LY)


See all GABRA4 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
S398A-34
Antibody Isotype
IgG1
Application
ICC/IF, IHC, WB

Basic Information

Immunogen
Fusion protein amino acids 410-450 (Cytoplasmic C-terminus) of rat GABA-A-Receptor Alpha 4
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
gamma-aminobutyric acid type A receptor subunit alpha4
Introduction
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011]
Entrez Gene ID
Human2557
Mouse14397
Rat140675
UniProt ID
HumanP48169
MouseQ9D6F4
RatP28471
Alternative Names
Gamma-Aminobutyric Acid Type A Receptor Alpha4 Subunit; Gamma-Aminobutyric Acid (GABA) A Receptor, Alpha 4; GABA(A) Receptor Subunit Alpha-4; GABA(A) Receptor, Alpha 4;
Function
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Biological Process
Chemical synaptic transmission Source: GO_Central
Chloride transmembrane transport Source: GO_Central
Gamma-aminobutyric acid signaling pathway Source: GO_Central
Ion transmembrane transport Source: GO_Central
Nervous system process Source: GO_Central
Regulation of membrane potential Source: GO_Central
Regulation of postsynaptic membrane potential Source: GO_Central
Signal transduction Source: GO_Central
Synaptic transmission, GABAergic Source: GO_Central
Cellular Location
Postsynaptic cell membrane; Cell membrane
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-GABRA4 Recombinant Antibody (S398A-34)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare